| Prebiotic supplementation in full-term neonates: a systematic review of randomized controlled trials. | |
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MedLine Citation:
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PMID: 19652109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To systematically review randomized controlled trials evaluating the efficacy and safety of prebiotic supplementation in full-term neonates. DATA SOURCES: Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, and CINAHL databases and proceedings of relevant conferences. STUDY SELECTION: Eleven of 24 identified trials (n = 1459) were eligible for inclusion. Intervention Trials comparing formula milk supplemented with or without prebiotics, commenced at or before age 28 days and continued for 2 weeks or longer. MAIN OUTCOME MEASURES: Stool colony counts (bifidobacteria, lactobacilli, and pathogens), pH, consistency, frequency, anthropometry, and symptoms of intolerance. RESULTS: Six trials reported significant increases and 2 reported a trend toward increases in bifidobacteria counts after supplementation. Meta-analysis estimated significant reduction in stool pH in infants who received prebiotic supplementation (weighted mean difference, -0.65; 95% confidence interval, -0.76 to -0.54; 6 trials). Infants who receive a supplement had slightly better weight gain than did controls (weighted mean difference, 1.07 g; 95% confidence interval, 0.14-1.99; 4 trials) with softer and frequent stools similar to breastfed infants. All but 1 trial reported that prebiotic supplementation was well tolerated. In that trial, diarrhea (18% vs 4%; P = .008), irritability (16% vs 4%; P = .03), and eczema (18% vs 7%; P = .046) were reported more frequently by parents of infants who received prebiotic supplements. CONCLUSIONS: Prebiotic-supplemented formula is well tolerated by full-term infants. It increases stool colony counts of bifidobacteria and lactobacilli and results in stools similar to those of breastfed neonates without affecting weight gain. Larger trials with long-term follow-up are needed to determine whether these short-term benefits are sustained. |
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Authors:
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Shripada Rao; Ravisha Srinivasjois; Sanjay Patole |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Archives of pediatrics & adolescent medicine Volume: 163 ISSN: 1538-3628 ISO Abbreviation: Arch Pediatr Adolesc Med Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-04 Completed Date: 2009-09-15 Revised Date: 2010-03-05 |
Medline Journal Info:
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Nlm Unique ID: 9422751 Medline TA: Arch Pediatr Adolesc Med Country: United States |
Other Details:
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Languages: eng Pagination: 755-64 Citation Subset: AIM; IM |
Affiliation:
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Department of Neonatal Pediatrics, Princess Margaret Hospital for Children, Roberts Road, Subiaco, Perth, Western Australia 6008, Australia. Shripada.Rao@health.wa.gov.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anthropometry Bifidobacterium / isolation & purification Dietary Supplements* Feces / microbiology* Female Humans Hydrogen-Ion Concentration Infant Formula* Infant, Newborn Lactobacillus / isolation & purification Male Probiotics / therapeutic use* Randomized Controlled Trials as Topic |
| Comments/Corrections | |
Comment In:
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Evid Based Nurs. 2010 Feb;13(1):12-3
[PMID:
20179056
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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