Document Detail

Prebiotic supplementation in full-term neonates: a systematic review of randomized controlled trials.
MedLine Citation:
PMID:  19652109     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To systematically review randomized controlled trials evaluating the efficacy and safety of prebiotic supplementation in full-term neonates. DATA SOURCES: Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, and CINAHL databases and proceedings of relevant conferences. STUDY SELECTION: Eleven of 24 identified trials (n = 1459) were eligible for inclusion. Intervention Trials comparing formula milk supplemented with or without prebiotics, commenced at or before age 28 days and continued for 2 weeks or longer. MAIN OUTCOME MEASURES: Stool colony counts (bifidobacteria, lactobacilli, and pathogens), pH, consistency, frequency, anthropometry, and symptoms of intolerance. RESULTS: Six trials reported significant increases and 2 reported a trend toward increases in bifidobacteria counts after supplementation. Meta-analysis estimated significant reduction in stool pH in infants who received prebiotic supplementation (weighted mean difference, -0.65; 95% confidence interval, -0.76 to -0.54; 6 trials). Infants who receive a supplement had slightly better weight gain than did controls (weighted mean difference, 1.07 g; 95% confidence interval, 0.14-1.99; 4 trials) with softer and frequent stools similar to breastfed infants. All but 1 trial reported that prebiotic supplementation was well tolerated. In that trial, diarrhea (18% vs 4%; P = .008), irritability (16% vs 4%; P = .03), and eczema (18% vs 7%; P = .046) were reported more frequently by parents of infants who received prebiotic supplements. CONCLUSIONS: Prebiotic-supplemented formula is well tolerated by full-term infants. It increases stool colony counts of bifidobacteria and lactobacilli and results in stools similar to those of breastfed neonates without affecting weight gain. Larger trials with long-term follow-up are needed to determine whether these short-term benefits are sustained.
Shripada Rao; Ravisha Srinivasjois; Sanjay Patole
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Archives of pediatrics & adolescent medicine     Volume:  163     ISSN:  1538-3628     ISO Abbreviation:  Arch Pediatr Adolesc Med     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-04     Completed Date:  2009-09-15     Revised Date:  2010-03-05    
Medline Journal Info:
Nlm Unique ID:  9422751     Medline TA:  Arch Pediatr Adolesc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  755-64     Citation Subset:  AIM; IM    
Department of Neonatal Pediatrics, Princess Margaret Hospital for Children, Roberts Road, Subiaco, Perth, Western Australia 6008, Australia.
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MeSH Terms
Bifidobacterium / isolation & purification
Dietary Supplements*
Feces / microbiology*
Hydrogen-Ion Concentration
Infant Formula*
Infant, Newborn
Lactobacillus / isolation & purification
Probiotics / therapeutic use*
Randomized Controlled Trials as Topic
Comment In:
Evid Based Nurs. 2010 Feb;13(1):12-3   [PMID:  20179056 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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