Document Detail

Prebiotic origin of glycolytic metabolism: histidine and cysteine can produce acetyl CoA from glucose via reactions homologous to non-phosphorylated Entner-Doudoroff pathway.
MedLine Citation:
PMID:  18515857     Owner:  NLM     Status:  MEDLINE    
Conversion of glucose to pyruvate via reactions homologous to the non-phosphorylated Entner-Doudoroff (non-P ED) pathway could be achieved in the presence of two amino acid catalysts, cysteine and histidine: cystine oxidizes glucose to gluconic acid by the reaction homologous to glucose dehydrogenase and histidine changes gluconic acid to 2-keto-3-deoxy gluconic acid, then to pyruvate by the reaction homologous to gluconic acid dehydratase and 2-keto-3-deoxy gluconate aldolase, respectively. Pyruvate can be converted to acetyl CoA by the reaction with CoA, TPP and FAD in the presence of cysteine and histidine, which resembles pyruvate dehydrogenase reaction. It was found that gluconic acid dehydration alone is non-specific, in contrast to other reactions. The non-P ED pathway is used by some extreme thermophiles in bacteria and archaea, usually thought as the oldest among the contemporary organisms. This study suggests the possible contribution of amino acid to the origin of the glycolytic pathway.
Mikio Shimizu; Akihiko Yamagishi; Kenji Kinoshita; Yasuo Shida; Tairo Oshima
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Publication Detail:
Type:  Journal Article     Date:  2008-05-31
Journal Detail:
Title:  Journal of biochemistry     Volume:  144     ISSN:  0021-924X     ISO Abbreviation:  J. Biochem.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-01     Completed Date:  2008-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376600     Medline TA:  J Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  383-8     Citation Subset:  IM    
Institute of Space and Aeronautical Science, Yoshinodai, Sagamihara, Kanagawa, 229-8510 and Tokyo University of Pharmacy and Life Science,1432-1, Horinouchi, Hachiouji, Tokyo, 192-0392.
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MeSH Terms
Acetyl Coenzyme A / chemistry*
Amino Acids / chemistry
Biochemistry / methods*
Chromatography, Thin Layer / methods
Cysteine / chemistry*
Gluconates / chemistry
Glucose / chemistry*
Histidine / chemistry*
Mass Spectrometry
Models, Biological
NAD / chemistry
Time Factors
Reg. No./Substance:
0/Amino Acids; 0/Gluconates; 50-99-7/Glucose; 52-90-4/Cysteine; 526-95-4/gluconic acid; 53-84-9/NAD; 71-00-1/Histidine; 72-89-9/Acetyl Coenzyme A

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