Document Detail

Preaxial ray reduction defects as part of valproic acid embryofetopathy.
MedLine Citation:
PMID:  8309898     Owner:  NLM     Status:  MEDLINE    
It is well known that prenatal exposure of valproic acid (VPA) may be associated with the occurrence of neural tube defects (Robert and Gibaud, 1982). Additional adverse effects related to VPA exposure include craniofacial abnormalities, skeletal defects, brain defects, cardiovascular defects, and urogenital defects (DiLiberti et al., 1984; Winter et al., 1987; Huot et al., 1987; Jager-Roman et al., 1986; Martinez-Frias, 1990). Recently, radial ray reduction has been reported as a severe type of skeletal defect associated with VPA exposure (Jager-Roman et al., 1986; Huot et al., 1987; Verloes et al., 1990). We report two additional cases of this severe limb reduction defect as part of a broader pattern of altered morphogenesis in fetuses exposed to VPA and to confirm an association between such severe specific skeletal defects and VPA exposure. We briefly review teratologic studies in experimental animals which document the biologic plausibility of this association, and suggest that fetuses exposed to VPA undergo detailed prenatal ultrasonographic evaluation of the limbs.
R Sharony; A Garber; D Viskochil; R Schreck; L D Platt; R Ward; B A Buehler; J M Graham
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  13     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-03-17     Completed Date:  1994-03-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  909-18     Citation Subset:  IM    
Medical Genetics Birth Defects Center, Cedars-Sinai Medical Center, Los Angeles, CA.
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MeSH Terms
Abnormalities, Drug-Induced* / radiography,  ultrasonography
Abnormalities, Multiple / chemically induced*
Abortion, Therapeutic
Extremities / radiography,  ultrasonography
Facial Bones / abnormalities
Fetal Diseases / chemically induced*,  ultrasonography
Infant, Newborn
Limb Deformities, Congenital*
Pregnancy Complications
Pregnancy Outcome
Pregnancy Trimester, Second
Seizures / drug therapy
Ultrasonography, Prenatal
Valproic Acid / adverse effects*
Grant Support
Reg. No./Substance:
99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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