| Preaxial ray reduction defects as part of valproic acid embryofetopathy. | |
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MedLine Citation:
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PMID: 8309898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is well known that prenatal exposure of valproic acid (VPA) may be associated with the occurrence of neural tube defects (Robert and Gibaud, 1982). Additional adverse effects related to VPA exposure include craniofacial abnormalities, skeletal defects, brain defects, cardiovascular defects, and urogenital defects (DiLiberti et al., 1984; Winter et al., 1987; Huot et al., 1987; Jager-Roman et al., 1986; Martinez-Frias, 1990). Recently, radial ray reduction has been reported as a severe type of skeletal defect associated with VPA exposure (Jager-Roman et al., 1986; Huot et al., 1987; Verloes et al., 1990). We report two additional cases of this severe limb reduction defect as part of a broader pattern of altered morphogenesis in fetuses exposed to VPA and to confirm an association between such severe specific skeletal defects and VPA exposure. We briefly review teratologic studies in experimental animals which document the biologic plausibility of this association, and suggest that fetuses exposed to VPA undergo detailed prenatal ultrasonographic evaluation of the limbs. |
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Authors:
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R Sharony; A Garber; D Viskochil; R Schreck; L D Platt; R Ward; B A Buehler; J M Graham |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Prenatal diagnosis Volume: 13 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1994-03-17 Completed Date: 1994-03-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 909-18 Citation Subset: IM |
Affiliation:
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Medical Genetics Birth Defects Center, Cedars-Sinai Medical Center, Los Angeles, CA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced*
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radiography,
ultrasonography Abnormalities, Multiple / chemically induced* Abortion, Therapeutic Adolescent Adult Extremities / radiography, ultrasonography Facial Bones / abnormalities Female Fetal Diseases / chemically induced*, ultrasonography Humans Infant, Newborn Limb Deformities, Congenital* Male Pregnancy Pregnancy Complications Pregnancy Outcome Pregnancy Trimester, Second Seizures / drug therapy Ultrasonography, Prenatal Valproic Acid / adverse effects* |
| Grant Support | |
ID/Acronym/Agency:
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GM08243/GM/NIGMS NIH HHS; P01 HD22657-06/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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