Document Detail


Pre-wallerian degeneration in the neonatal brain following perinatal cerebral hypoxia-ischemia demonstrated with MRI.
MedLine Citation:
PMID:  16813973     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: Pre-Wallerian degeneration was studied in term and near-term neonates with hypoxic-ischemic brain injury, and related to neurodevelopmental outcome. SUBJECTS: Thirty-nine surviving patients with hypoxic-ischemic encephalopathy or seizures and MRI-documented brain abnormalities were included. Patients were grouped according to the MRI findings: group 1 (n = 23), ischemic stroke or watershed infarcts; group 2 (n = 8), lesions of the basal ganglia; group 3 (n = 8), predominantly white matter lesions. METHODS: Cranial MRI, including diffusion-weighted MRI, was performed between 1 and 10 days after birth. ADC maps were created, and presence or absence of pre-Wallerian degeneration in the cerebral peduncles was assessed. RESULTS: Of the 15 neonates with pre-Wallerian degeneration, 14 had permanent abnormalities of motor development, whereas 1 had a transient asymmetry. Six neonates with a poor outcome had no pre-Wallerian degeneration, which may be contributed to the timing of the MRI in 2. Eighteen neonates had no pre-Wallerian degeneration and a normal motor development. CONCLUSION: Pre-Wallerian degeneration of the cerebral peduncles in neonates with hypoxia-ischemia is almost invariably associated with a poor motor development. In neonates with abnormalities of the basal ganglia or white matter and a poor outcome, pre-Wallerian degeneration is less common than in neonates with stroke or watershed infarcts and a poor motor outcome.
Authors:
Floris Groenendaal; Manon J Benders; Linda S de Vries
Related Documents :
17437913 - Neuroimage findings in 2-methyl-3-hydroxybutyryl-coa dehydrogenase deficiency.
8836973 - Akinetic mutism with bithalamic infarction. neurophysiological correlates.
20172893 - Could ct scan avoid unnecessary flexible bronchoscopy in children with active pulmonary...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in perinatology     Volume:  30     ISSN:  0146-0005     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  146-50     Citation Subset:  IM    
Affiliation:
Department of Neonatology, Division of Perinatology and Gynecology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Diffusion Magnetic Resonance Imaging* / methods
Humans
Hypoxia-Ischemia, Brain / complications,  radiography*
Infant, Newborn
Infant, Premature / growth & development*
Infant, Premature, Diseases / radiography*
Wallerian Degeneration / etiology,  radiography*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Photoprotection of parenteral nutrition enhances advancement of minimal enteral nutrition in preterm...
Next Document:  Short- and long-term consequences of hypotension in ELBW infants.