| Pretransplantation functional imaging predicts outcome following autologous stem cell transplantation for relapsed and refractory Hodgkin lymphoma. | |
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MedLine Citation:
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PMID: 20733154 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To identify prognostic factors for patients transplanted for relapsed or refractory Hodgkin lymphoma we carried out a combined analysis of patients followed prospectively on 3 consecutive protocols at Memorial Sloan-Kettering Cancer Center. One hundred fifty-three patients with chemosensitive disease after ICE (ifosfamide, carboplatin, and etoposide)-based salvage therapy (ST) proceeded to high-dose chemoradiotherapy followed by autologous stem cell transplantation (ASCT). Patients were evaluated with computed tomography and functional imaging (gallium or fluorodeoxyglucose-positron emission tomography) prior to ST and again before ASCT. Functional imaging status before ASCT was the only factor significant for event-free survival (EFS) and overall survival by multivariate analysis and clearly identifies poor risk patients (5-year EFS 31% and 75% for FI-positive and negative patients respectively). Administration of involved-field radiotherapy with ASCT was marginally significant for EFS (P = .055). Studies evaluating novel STs, conditioning regimens, post-ASCT maintenance, or allogeneic stem cell transplantation are warranted for patients who fail to normalize pre-ASCT functional imaging. |
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Authors:
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Alison J Moskowitz; Joachim Yahalom; Tarun Kewalramani; Jocelyn C Maragulia; Jill M Vanak; Andrew D Zelenetz; Craig H Moskowitz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-23 |
Journal Detail:
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Title: Blood Volume: 116 ISSN: 1528-0020 ISO Abbreviation: Blood Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-03 Completed Date: 2011-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
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Languages: eng Pagination: 4934-7 Citation Subset: AIM; IM |
Affiliation:
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Lymphoma Service of the Division of Hematologic Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. moskowia@mskcc.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antineoplastic Combined Chemotherapy Protocols / therapeutic use Carboplatin / administration & dosage Combined Modality Therapy Disease-Free Survival Etoposide / administration & dosage Female Hematopoietic Stem Cell Transplantation* Hodgkin Disease / radiography*, radionuclide imaging*, therapy* Humans Ifosfamide / administration & dosage Kaplan-Meier Estimate Male Middle Aged Neoplasm Recurrence, Local / surgery Positron-Emission Tomography Prognosis Radiotherapy Salvage Therapy / methods Tomography, X-Ray Computed Transplantation Conditioning Transplantation, Autologous Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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33419-42-0/Etoposide; 3778-73-2/Ifosfamide; 41575-94-4/Carboplatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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