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Pre-threshold retinopathy in premature infants with intra-uterine growth restriction.
MedLine Citation:
PMID:  25196981     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: To determine, among very preterm newborns, if those who are growth restricted are at increased risk of retinopathy of prematurity (ROP), and to explore if the mixed findings of prior studies are the consequence of sampling based upon birth weight instead of gestational age.
METHODS: Using data from the ELGAN Study, we created logistic regression models of pre-threshold ROP risk to adjust for confounders and calculate odds ratios and 99% confidence intervals. We created scatter plots to display the gestational age/birth weight relationship in infants enrolled in studies with different selection criteria.
RESULTS: Low gestational age (23-24 weeks, OR 11.6 (2.9, 47); 25-26 weeks, 8.1 (2.1, 32)) and severe growth restriction (birth weight Z-score <-2, OR 9.1 (1.1, 76)) were associated with increased risk of pre-threshold ROP. We documented in scatter plots that a sample defined by birth weight has an excess of gestationally-older, severely growth-restricted newborns.
CONCLUSION: In this sample, low gestational age and severe growth restriction were associated with increased risk of pre-threshold ROP. This article is protected by copyright. All rights reserved.
Authors:
Jennifer W Lee; Deborah VanderVeen; Elizabeth N Allred; Alan Leviton; Olaf Dammann
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-4
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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