| Pre-symptomatic increase in urine-orosomucoid excretion in pre-eclamptic women. | |
| | |
MedLine Citation:
|
PMID: 17653877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Although the pre-eclamptic pathogenesis begins at least around the 18th week of pregnancy, clinically evident disease often does not appear until the third trimester. This long pre-symptomatic latency period has led to intensive research for early markers of evolving disease. We evaluated urine excretion and plasma levels of orosomucoid and albumin longitudinally in healthy and pre-eclamptic pregnancies. Orosomucoid is an acute phase protein involved in inflammation and protection of the endothelium. METHODS: From a prospective, longitudinal cohort study consisting of 1,631 women, 32 women developed pre-eclampsia, and 5 controls for every case of pre-eclampsia were found. Blood samples were collected 4 times and urine samples 6 times from the 18/19th week and throughout pregnancy. Orosomucoid and albumin in plasma were analysed by standard methods, and in urine by sandwich ELISA. RESULTS: Orosomucoid/creatinin excretion ratio was significantly higher early in pre-eclamptic pregnancies (from the 20th week of pregnancy, p=0.0053) compared with healthy pregnancies, the difference increased throughout pregnancy. Albumin/creatinin ratio increased subsequent to the increase in orosomucoid. In the plasma samples, orosomucoid was significantly higher late in pre-eclamptic pregnancies (>or=36th week, p=0.0275). CONCLUSIONS: Pre-eclampsia is associated with a pre-symptomatic increase in the urine excretion of orosomucoid, and orosomucoid excretion precedes that of albumin. Orosomucoid excretion can probably be used as a prognostic tool in combination with other screening methods, and seems to be a more sensitive marker for evolving pre-eclampsia than albumin. Plasma orosomucoid is significantly increased late in pre-eclampsia. Thus, the increased excretion of orosomucoid must primarily originate from altered renal processing of orosomucoid. |
| | |
Authors:
|
Camilla S Kronborg; Jim Allen; Erik Vittinghus; Ulla Breth Knudsen |
Related Documents
:
|
6112487 - Decrease prostacyclin production: a characteristic of chronic placental insufficiency s... 12768557 - Clinical significance of normalization of uterine artery pulsatility index with materna... 12362987 - Collagen of umbilical cord vein and its alterations in pre-eclampsia. 713277 - Pre-eclampsia with the nephrotic syndrome. 17096817 - Clinical features of polyhydramnios associated with fetal anomalies. 21592687 - Sonographic markers of aneuploidies at 6-10weeks of gestation. |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Acta obstetricia et gynecologica Scandinavica Volume: 86 ISSN: 0001-6349 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 2007 |
Date Detail:
|
Created Date: 2007-07-26 Completed Date: 2007-10-09 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: Denmark |
Other Details:
|
Languages: eng Pagination: 930-7 Citation Subset: IM |
Affiliation:
|
Department of Gynecology and Obstetrics, Randers County Hospital, Randers, Denmark. csk@mb.au.dk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Biological Markers / blood, urine Case-Control Studies Cohort Studies Creatinine / blood, urine Enzyme-Linked Immunosorbent Assay Female Humans Longitudinal Studies Orosomucoid / urine* Pre-Eclampsia / blood, urine* Predictive Value of Tests Pregnancy Pregnancy Trimester, Second Prenatal Diagnosis* Prospective Studies Serum Albumin |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Orosomucoid; 0/Serum Albumin; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The use of atosiban and ritodrine in external cephalic version.
Next Document: Pregnancy and oral health: utilisation of dental services during pregnancy in northern Greece.