| Pre-pubertal castration causes the age-dependent changes in hippocampal long-term potentiation. | |
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MedLine Citation:
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PMID: 23325723 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The effects of pre-pubertal castration on hippocampal CA3-CA1 synaptic transmission and plasticity were studied at different ages in vitro. The field excitatory postsynaptic potentials (fEPSP); and population spikes (PS); were simultaneously recorded from stratum radiatum and stratum pylamidale of area CA1 following stimulation of Schaffer collaterals in slices taken from sham-castrated and castrated rats at postnatal days (PND); 28, 35, 45 and 60. Castration had no effect on baseline responses at different ages except at PND 60 that a decrease in the fEPSP slope was seen. Pre-pubertal castration caused age-specific changes in CA1-LTP induction. The castration did decrease both fEPSP-LTP and PS-LTP at PND 35 but a decrease was seen only in PS-LTP at PND 60. NMDA receptor antagonist AP5 (25 µM); completely blocked both fEPSP-LTP and PS-LTP at PND 60 and only PS-LTP at PND 35 in both sham-castrated and castrated groups. While AP5 blocked fEPSP-LTP at PND 35 in sham-castrated group, it failed to inhibit fEPSP-LTP at PND 35 in castrated one. These findings suggest that pre-pubertal castration causes the age-dependent changes in CA1-LTP induction, which might arise from alterations in the NMDA receptors. Synapse, 2013. © 2013 Wiley Periodicals, Inc. |
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Authors:
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Farshad Moradpour; Yaghoub Fathollahi; Nasser Naghdi; Nargess Hosseinmardi; Mohammad Javan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-17 |
Journal Detail:
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Title: Synapse (New York, N.Y.) Volume: - ISSN: 1098-2396 ISO Abbreviation: Synapse Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8806914 Medline TA: Synapse Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2013 Wiley Periodicals, Inc. |
Affiliation:
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Department of Physiology, School of Medical Sciences, Tarbiat Modares University, P O Box: 14115-111, Tehran, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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