Document Detail


Pre-pubertal castration causes the age-dependent changes in hippocampal long-term potentiation.
MedLine Citation:
PMID:  23325723     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The effects of pre-pubertal castration on hippocampal CA3-CA1 synaptic transmission and plasticity were studied at different ages in vitro. The field excitatory postsynaptic potentials (fEPSP); and population spikes (PS); were simultaneously recorded from stratum radiatum and stratum pylamidale of area CA1 following stimulation of Schaffer collaterals in slices taken from sham-castrated and castrated rats at postnatal days (PND); 28, 35, 45 and 60. Castration had no effect on baseline responses at different ages except at PND 60 that a decrease in the fEPSP slope was seen. Pre-pubertal castration caused age-specific changes in CA1-LTP induction. The castration did decrease both fEPSP-LTP and PS-LTP at PND 35 but a decrease was seen only in PS-LTP at PND 60. NMDA receptor antagonist AP5 (25 µM); completely blocked both fEPSP-LTP and PS-LTP at PND 60 and only PS-LTP at PND 35 in both sham-castrated and castrated groups. While AP5 blocked fEPSP-LTP at PND 35 in sham-castrated group, it failed to inhibit fEPSP-LTP at PND 35 in castrated one. These findings suggest that pre-pubertal castration causes the age-dependent changes in CA1-LTP induction, which might arise from alterations in the NMDA receptors. Synapse, 2013. © 2013 Wiley Periodicals, Inc.
Authors:
Farshad Moradpour; Yaghoub Fathollahi; Nasser Naghdi; Nargess Hosseinmardi; Mohammad Javan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Synapse (New York, N.Y.)     Volume:  -     ISSN:  1098-2396     ISO Abbreviation:  Synapse     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806914     Medline TA:  Synapse     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
Affiliation:
Department of Physiology, School of Medical Sciences, Tarbiat Modares University, P O Box: 14115-111, Tehran, Iran.
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