Document Detail

Pre-pregnancy body mass index, gestational weight gain, and other maternal characteristics in relation to infant birth weight.
MedLine Citation:
PMID:  17713848     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Infant birth weight is influenced by modifiable maternal pre-pregnancy behaviors and characteristics. We evaluated the relationship among pre-pregnancy body mass index (BMI), gestational weight gain, and infant birth weight, in a prospective cohort study. METHODS: Women were enrolled at < or =20 weeks gestation, completed in-person interviews and had their medical records reviewed after delivery. Infant birth weight was first analyzed as a continuous variable, and then grouped into Low birth weight (LBW) (<2,500 g), normal birth weight (2,500-3,999 g), and macrosomia (> or =4,000 g) in categorical analysis. Pre-pregnancy BMI and gestational weight gain were categorized based on Institute of Medicine BMI groups and gestational weight gain guidelines. Associations among infant birth weight and pre-pregnancy BMI, gestational weight gain, and other factors were evaluated using multivariate regression. Risk ratios were estimated using generalized linear modeling procedures. RESULTS: Pre-pregnancy BMI was independently and positively associated with infant birth weight (beta = 44.7, P = 0.001) after adjusting for confounders, in a quadratic model. Gestational weight gain was positively associated with infant birth weight (beta = 19.5, P < 0.001). Lower infant birth weight was associated with preterm birth (beta = -965.4, P < 0.001), nulliparity (beta = -48.6, P = 0.015), and female babies (beta = -168.7, P < 0.001). Less than median gestational weight gain was associated with twice the risk of LBW (RR = 2.04, 95% CI 1.34-3.11). Risk of macrosomia increased with increasing pre-pregnancy BMI and gestational weight gain (P for linear trend <0.001). CONCLUSIONS: These findings support the need to balance pre-pregnancy weight and gestational weight gain against the risk of LBW and macrosomia among lean and obese women, respectively.
Ihunnaya O Frederick; Michelle A Williams; Anne E Sales; Diane P Martin; Marcia Killien
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-08-23
Journal Detail:
Title:  Maternal and child health journal     Volume:  12     ISSN:  1092-7875     ISO Abbreviation:  Matern Child Health J     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-26     Completed Date:  2009-03-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9715672     Medline TA:  Matern Child Health J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  557-67     Citation Subset:  IM    
Department of Health Services, University of Washington School of Public Health and Community Medicine, Seattle, WA, USA.
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MeSH Terms
Birth Weight / physiology*
Body Mass Index*
Fetus / physiology*
Logistic Models
Pregnancy Outcome
Weight Gain / physiology*
Young Adult
Grant Support

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