Document Detail

Pre- and postoperative changes in serum myelin basic protein immunoreactivity in neurosurgical patients.
MedLine Citation:
PMID:  6202857     Owner:  NLM     Status:  MEDLINE    
In 44 patients undergoing neurosurgical procedures for intracranial tumors, subarachnoid hemorrhage, or spinal and peripheral nerve lesions, serum myelin basic protein (MBP) immunoreactivity was measured preoperatively and serially in the first 10 postoperative days. The double-antibody radioimmunoassay method was used, with a detection limit of 2.5 ng/ml in serum. Clinical evaluation was carried out at admission and on successive days during the period of neurosurgical management; outcome was assessed later. In the early postoperative phase, there was a fall in MBP immunoreactivity in all groups of patients. In the groups with intracranial tumor and subarachnoid hemorrhage, there was a subsequent rise in MBP immunoreactivity before the end of the 10-day period, which was not found in the group with spinal and peripheral nerve lesions.
N R Hoyle; P A Seeldrayers; A H Moussa; E A Paul; D G Thomas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  61     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-07-26     Completed Date:  1984-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  49-52     Citation Subset:  AIM; IM    
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MeSH Terms
Adenoma / immunology,  surgery
Brain Neoplasms / immunology,  surgery
Central Nervous System Diseases / immunology*,  surgery
Glioma / immunology,  surgery
Meningioma / immunology,  surgery
Middle Aged
Myelin Basic Proteins / immunology*
Spinal Cord Diseases / immunology,  surgery
Spinal Diseases / immunology,  surgery
Subarachnoid Hemorrhage / immunology,  surgery
Reg. No./Substance:
0/Myelin Basic Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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