| Pre- and/or postnatal protein restriction in rats impairs learning and motivation in male offspring. | |
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MedLine Citation:
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PMID: 21078378 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Suboptimal developmental environments program offspring to lifelong health complications including affective and cognitive disorders. Little is known about the effects of suboptimal intra-uterine environments on associative learning and motivational behavior. We hypothesized that maternal isocaloric low protein diet during pregnancy and lactation would impair offspring associative learning and motivation as measured by operant conditioning and the progressive ratio task, respectively. Control mothers were fed 20% casein (C) and restricted mothers (R) 10% casein to provide four groups: CC, RR, CR, and RC (first letter pregnancy diet and second letter lactation diet), to evaluate effects of maternal diet on male offspring behavior. Impaired learning was observed during fixed ratio-1 operant conditioning in RC offspring that required more sessions to learn vs. the CC offspring (9.4±0.8 and 3.8±0.3 sessions, respectively, p<0.05). Performance in fixed ratio-5 conditioning showed the RR (5.4±1.1), CR (4.0±0.8), and RC (5.0±0.8) offspring required more sessions to reach performance criterion than CC offspring (2.5±0.5, p<0.05). Furthermore, motivational effects during the progressive ratio test revealed less responding in the RR (48.1±17), CR (74.7±8.4), and RC (65.9±11.2) for positive reinforcement vs. the CC offspring (131.5±7.5, p<0.05). These findings demonstrate negative developmental programming effects due to perinatal isocaloric low protein diet on learning and motivation behavior with the nutritional challenge in the prenatal period showing more vulnerability in offspring behavior. |
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Authors:
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L A Reyes-Castro; J S Rodriguez; G L Rodríguez-González; R D Wimmer; T J McDonald; F Larrea; P W Nathanielsz; E Zambrano |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-11-13 |
Journal Detail:
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Title: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience Volume: 29 ISSN: 1873-474X ISO Abbreviation: Int. J. Dev. Neurosci. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-02-21 Completed Date: 2011-05-31 Revised Date: 2012-04-04 |
Medline Journal Info:
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Nlm Unique ID: 8401784 Medline TA: Int J Dev Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 177-82 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 ISDN. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, 14000, Mexico. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Conditioning, Operant Diet, Protein-Restricted / adverse effects* Female Humans Lactation Learning / physiology* Male Motivation* Pregnancy Prenatal Exposure Delayed Effects Rats Rats, Wistar |
| Grant Support | |
ID/Acronym/Agency:
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HD21350/HD/NICHD NIH HHS; P01 HD021350-18/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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