Document Detail


Pre- and postnatal low protein diet affect pancreatic islet blood flow and insulin release in adult rats.
MedLine Citation:
PMID:  8756549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pancreatic islet blood flow and insulin secretion of adult rats submitted to an isocaloric low protein diet (8% vs. 20%) during pre- and postnatal life were investigated by the nonradioactive microsphere technique. In the basal state, female rats chronically exposed to a low protein diet (LP) displayed a specific marked decrease in islet blood flow (10 +/- 2 vs. 29 +/- 5 microliters/min.g pancreas; P < 0.01) and overall pancreatic blood flow (P < 0.01). The plasma insulin level, however, was not affected. During a glucose challenge, the control animals enhanced their islet blood flow 2.3-fold, whereas the LP group reached control values with a 6-fold increase. Plasma insulin levels rose similarly in the control and LP animals. A third group of animals designated the recuperation group, exposed to a low protein diet only in utero, displayed islet blood flow comparable to control values, but increased basal plasma insulin (2.0 +/- 0.3 vs. 1.2 +/- 0.1 ng/ml; P < 0.05). These data are consistent with the possibility of dissociation of islet blood flow and insulin release under basal conditions, which may not be the case after a glucose challenge. Furthermore, the low blood flow values in the LP group may reflect an adaptive physiological response, an impaired pancreatic vasculogenesis, or a dysfunction of endothelial cells.
Authors:
V Iglésias-Barreira; M T Ahn; B Reusens; S Dahri; J J Hoet; C Remacle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrinology     Volume:  137     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-11-13     Completed Date:  1996-11-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3797-801     Citation Subset:  AIM; IM    
Affiliation:
Laboratoire de Biologie Cellulaire, Université Catholique de Louvain, Louvain-La Neuve, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism*
Animals
Animals, Newborn* / anatomy & histology
Body Weight
Dietary Proteins / administration & dosage*,  pharmacology
Female
Glucose / metabolism
Homeostasis
Insulin / metabolism*
Islets of Langerhans / blood supply*,  metabolism*
Organ Size
Pregnancy
Rats
Rats, Wistar
Regional Blood Flow / drug effects
Chemical
Reg. No./Substance:
0/Dietary Proteins; 11061-68-0/Insulin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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