Document Detail

Pre- and postnatal low protein diet affect pancreatic islet blood flow and insulin release in adult rats.
MedLine Citation:
PMID:  8756549     Owner:  NLM     Status:  MEDLINE    
The pancreatic islet blood flow and insulin secretion of adult rats submitted to an isocaloric low protein diet (8% vs. 20%) during pre- and postnatal life were investigated by the nonradioactive microsphere technique. In the basal state, female rats chronically exposed to a low protein diet (LP) displayed a specific marked decrease in islet blood flow (10 +/- 2 vs. 29 +/- 5 microliters/min.g pancreas; P < 0.01) and overall pancreatic blood flow (P < 0.01). The plasma insulin level, however, was not affected. During a glucose challenge, the control animals enhanced their islet blood flow 2.3-fold, whereas the LP group reached control values with a 6-fold increase. Plasma insulin levels rose similarly in the control and LP animals. A third group of animals designated the recuperation group, exposed to a low protein diet only in utero, displayed islet blood flow comparable to control values, but increased basal plasma insulin (2.0 +/- 0.3 vs. 1.2 +/- 0.1 ng/ml; P < 0.05). These data are consistent with the possibility of dissociation of islet blood flow and insulin release under basal conditions, which may not be the case after a glucose challenge. Furthermore, the low blood flow values in the LP group may reflect an adaptive physiological response, an impaired pancreatic vasculogenesis, or a dysfunction of endothelial cells.
V Iglésias-Barreira; M T Ahn; B Reusens; S Dahri; J J Hoet; C Remacle
Related Documents :
12175989 - Pancreatic capillary blood flow in an improved model of necrotizing pancreatitis in the...
7717779 - Intravenous contrast medium aggravates the impairment of pancreatic microcirculation in...
1564299 - The role of the flow rate of the pneumohydraulic system on post-sphincter of oddi manom...
24875909 - The effects of prenatal exposure to low-level cadmium, lead and selenium on birth outco...
7106519 - Effects of various secretagogues and human carcinoid serum on lymph flow in the cat ileum.
14599719 - Effect of exogenous cholecystokinin on islet blood flow in anesthetized rats.
6869559 - Continuous measurement of arteriovenous oxygen difference and vo2 by microcomputer.
6693619 - Bileaflet, tilting disc and porcine aortic valve substitutes: in vitro hydrodynamic cha...
8133279 - Functional, metabolic, and circulatory changes associated with seizure activity in the ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrinology     Volume:  137     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-11-13     Completed Date:  1996-11-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3797-801     Citation Subset:  AIM; IM    
Laboratoire de Biologie Cellulaire, Université Catholique de Louvain, Louvain-La Neuve, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aging / metabolism*
Animals, Newborn* / anatomy & histology
Body Weight
Dietary Proteins / administration & dosage*,  pharmacology
Glucose / metabolism
Insulin / metabolism*
Islets of Langerhans / blood supply*,  metabolism*
Organ Size
Rats, Wistar
Regional Blood Flow / drug effects
Reg. No./Substance:
0/Dietary Proteins; 11061-68-0/Insulin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Diverse functions of aromatase: O-deethylation of 7-ethoxycoumarin.
Next Document:  Corticosterone selectively increases follicle-stimulating hormone beta-subunit messenger ribonucleic...