| Pre- and postnatal low protein diet affect pancreatic islet blood flow and insulin release in adult rats. | |
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MedLine Citation:
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PMID: 8756549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pancreatic islet blood flow and insulin secretion of adult rats submitted to an isocaloric low protein diet (8% vs. 20%) during pre- and postnatal life were investigated by the nonradioactive microsphere technique. In the basal state, female rats chronically exposed to a low protein diet (LP) displayed a specific marked decrease in islet blood flow (10 +/- 2 vs. 29 +/- 5 microliters/min.g pancreas; P < 0.01) and overall pancreatic blood flow (P < 0.01). The plasma insulin level, however, was not affected. During a glucose challenge, the control animals enhanced their islet blood flow 2.3-fold, whereas the LP group reached control values with a 6-fold increase. Plasma insulin levels rose similarly in the control and LP animals. A third group of animals designated the recuperation group, exposed to a low protein diet only in utero, displayed islet blood flow comparable to control values, but increased basal plasma insulin (2.0 +/- 0.3 vs. 1.2 +/- 0.1 ng/ml; P < 0.05). These data are consistent with the possibility of dissociation of islet blood flow and insulin release under basal conditions, which may not be the case after a glucose challenge. Furthermore, the low blood flow values in the LP group may reflect an adaptive physiological response, an impaired pancreatic vasculogenesis, or a dysfunction of endothelial cells. |
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Authors:
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V Iglésias-Barreira; M T Ahn; B Reusens; S Dahri; J J Hoet; C Remacle |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Endocrinology Volume: 137 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1996-11-13 Completed Date: 1996-11-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 3797-801 Citation Subset: AIM; IM |
Affiliation:
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Laboratoire de Biologie Cellulaire, Université Catholique de Louvain, Louvain-La Neuve, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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metabolism* Animals Animals, Newborn* / anatomy & histology Body Weight Dietary Proteins / administration & dosage*, pharmacology Female Glucose / metabolism Homeostasis Insulin / metabolism* Islets of Langerhans / blood supply*, metabolism* Organ Size Pregnancy Rats Rats, Wistar Regional Blood Flow / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Dietary Proteins; 11061-68-0/Insulin; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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