| Pre- and postischemic effects of the NMDA receptor antagonist dizocilpine maleate (MK-801) on collateral cerebral blood flow. | |
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MedLine Citation:
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PMID: 9384406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors studied the effects of pre- and postischemic administration of dizocilpine maleate (MK-801) on collateral and regional cerebral blood flow (CBF). The ischemic penumbra appears to benefit most from the neuroprotective effects of MK-801. The precise mechanism by which MK-801 provides this neuroprotection remains controversial. Alterations in CBF have been demonstrated with MK-801 administration, but whether the response is an increase or decrease in flow has remained unclear. A left-sided craniectomy was performed in 20 dogs. A branch of the middle cerebral artery (MCA) was cannulated and collateral blood supply-dependent tissue (CDT) was identified using the "shadow flow" technique. Regional CBF was measured using radiolabeled microspheres. Six dogs received MK-801 (1 mg/kg administered intravenously) before they underwent MCA branch occlusion; the remaining 14 dogs received MK-801 after they underwent MCA occlusion. Cerebral blood flow and vascular pressures were measured 30 and 60 minutes after MK-801 administration. In animals that received MK-801 before MCA occlusion, CBF did not change significantly from baseline values before or after occlusion. In contrast, in animals that received MK-801 after MCA occlusion, CBF was significantly reduced in all regions of the brain, including the CDT. Collateral blood supply-dependent tissue showed a 51.7% reduction in flow, whereas normal CBF was reduced by 29.7%. The MK-801 induced cerebral vasoconstriction in both groups. The neuroprotective effects of MK-801 do not appear to be caused by the augmentation of collateral or global cerebral circulation and, in fact, may block the glutamate-mediated vasodilation that occurs during ischemia. |
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Authors:
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S C Robertson; N M Wetjen; B J Beer; C M Loftus |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of neurosurgery Volume: 87 ISSN: 0022-3085 ISO Abbreviation: J. Neurosurg. Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1997-12-18 Completed Date: 1997-12-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0253357 Medline TA: J Neurosurg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 927-33 Citation Subset: AIM; IM |
Affiliation:
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Division of Neurosurgery, University of Iowa College of Medicine, Iowa City 52242, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Brain Ischemia / drug therapy*, physiopathology, radionuclide imaging Cerebral Arteries / drug effects Cerebrovascular Circulation / drug effects* Collateral Circulation / drug effects* Dizocilpine Maleate / administration & dosage, therapeutic use* Dogs Excitatory Amino Acid Antagonists / administration & dosage, therapeutic use* Injections, Intravenous Microspheres Neuroprotective Agents / administration & dosage, therapeutic use* Radiopharmaceuticals / diagnostic use Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors* Vascular Resistance / drug effects Vasoconstrictor Agents / therapeutic use Vasodilation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Excitatory Amino Acid Antagonists; 0/Neuroprotective Agents; 0/Radiopharmaceuticals; 0/Receptors, N-Methyl-D-Aspartate; 0/Vasoconstrictor Agents; 77086-22-7/Dizocilpine Maleate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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