Document Detail

Pre- and post-synaptic mechanisms regulating the clustering of type A gamma-aminobutyric acid receptors (GABAA receptors).
MedLine Citation:
PMID:  12887328     Owner:  NLM     Status:  MEDLINE    
Postsynaptic clustering of GABAA (type A gamma-aminobutyric acid) receptors is essential to ensure proper function of GABAergic synapses. This process is initiated during synapse formation and is maintained throughout life. The tubulin-associated protein gephyrin is required for clustering of GABAA receptors, but its specific role in this process is not understood. A second protein associated selectively with GABAA receptors at postsynaptic sites is dystrophin. It is present in a subset of GABAergic synapses along with several partners, forming the dystrophin-associated protein complex. In this review, we discuss recent advances in the role of neuronal activity and trans-synaptic signaling for the clustering of gephyrin and dystrophin during synaptogenesis and on the role of these proteins for plasticity and maintenance of mature synapses.
J-M Fritschy; C Schweizer; I Brünig; B Lüscher
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biochemical Society transactions     Volume:  31     ISSN:  0300-5127     ISO Abbreviation:  Biochem. Soc. Trans.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-30     Completed Date:  2004-05-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7506897     Medline TA:  Biochem Soc Trans     Country:  England    
Other Details:
Languages:  eng     Pagination:  889-92     Citation Subset:  IM    
Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
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MeSH Terms
Carrier Proteins / physiology
Dystrophin / chemistry,  metabolism
Membrane Proteins / physiology
Neurons / metabolism
Presynaptic Terminals / metabolism
Receptors, GABA-A / metabolism*
Synapses / metabolism*
Reg. No./Substance:
0/Carrier Proteins; 0/Dystrophin; 0/Membrane Proteins; 0/Receptors, GABA-A; 0/gephyrin

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