Document Detail

Pre- and post-discharge feeding of very preterm infants: impact on growth and bone mineralization.
MedLine Citation:
PMID:  12914556     Owner:  NLM     Status:  MEDLINE    
In this prospective study we examined (1) how the nutritional status of very preterm infants, judged by growth measures and biochemical values, evolved during the initial hospitalization; (2) the effect of feeding on growth after discharge from hospital; and (3) the risk factors associated with low lumbar bone mineral content (BMC) later in infancy. Sixty-four former preterm infants had their lumbar spine (L2-L4) BMC assessed by dual energy X-ray absorptiometry when they weighed between 5 and 7 kg. Predicted BMC values were calculated based on our previously reported reference lumbar BMC data. These values were used to convert the preterm infants' BMC values into percentages. The extremely preterm group (gestational age < or =28 weeks) had significantly more respiratory morbidity and longer duration of hospital stay than the more mature infants. Both groups developed growth retardation and malnutrition during the hospital stay. Exclusive breastfeeding after discharge from hospital supported linear catch-up growth and weight gain but was associated with a 7.0 (1.2-41.7)-fold risk of having low BMC values. The other factors associated with the risk of having low BMC values later in infancy were low serum phosphate levels at 6 weeks, with a 7.8 (1.6-37.0)-fold risk, and male gender, with a 4.3 (1.2-16.1)-fold risk. Appropriately designed interventional studies are needed to improve the growth and nutrition of these infants during initial hospitalization. In order to improve the postdischarge nutrition, we suggest that the amount and duration of multicomponent human milk fortification should be studied further to provide individualized nutrition throughout the catch-up growth period until the end of the first year of life.
Sangita Kurl; Kirsti Heinonen; Esko Länsimies
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  23     ISSN:  1475-0961     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-08-13     Completed Date:  2003-11-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  182-9     Citation Subset:  IM    
Department of Pediatrics, Kuopio University Hospital, Kuopio University, Kuopio, Finland.
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MeSH Terms
Absorptiometry, Photon
Bone Density
Breast Feeding
Calcification, Physiologic*
Gestational Age
Growth Disorders / diet therapy,  epidemiology,  prevention & control
Infant Food*
Infant Nutritional Physiological Phenomena
Infant, Newborn
Infant, Premature / growth & development*
Lumbar Vertebrae / growth & development
Osteocalcin / blood
Risk Factors
Vitamin D / blood
Reg. No./Substance:
104982-03-8/Osteocalcin; 1406-16-2/Vitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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