Document Detail

Pre- and perioperative factors affecting infection after living donor liver transplantation.
MedLine Citation:
PMID:  23044161     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Infectious complications, including sepsis, that often occur after liver transplantation (LT) comprise the most frequent causes of in-hospital death. This study investigated the predictors of post-transplantation infectious complications to establish a strategy with which to improve short-term outcomes after LT.
METHODS: We used univariate and multivariate analyses to assess pre- and perioperative risk factors for post-transplantation infectious complications in 100 consecutive patients who underwent living donor LT from February 2008 through February 2010 at our institute.
RESULTS: Multivariate analysis showed that low preoperative body cell mass and the absence of preoperative supplementation with branched-chain amino acids were of prognostic significance for post-transplantation sepsis. In addition, Child-Pugh classification C and massive operative blood loss were independent risk factors for post-transplantation bacteremia, and preoperative low body cell mass was an independent risk factor for in-hospital death from infection.
CONCLUSION: Pretransplantation nutritional intervention and decreases in operative blood loss would help prevent post-transplantation infectious complications from developing during living donor LT. Branched-chain amino acid supplementation before LT affects the occurrence of infectious complications.
Toshimi Kaido; Akira Mori; Yasuhiro Ogura; Kouhei Ogawa; Koichiro Hata; Atsushi Yoshizawa; Shintaro Yagi; Shinji Uemoto
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  28     ISSN:  1873-1244     ISO Abbreviation:  Nutrition     Publication Date:    2012 Nov-Dec
Date Detail:
Created Date:  2012-10-09     Completed Date:  2013-03-14     Revised Date:  2014-02-11    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1104-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Amino Acids, Branched-Chain / therapeutic use
Blood Loss, Surgical / prevention & control
Dietary Supplements
End Stage Liver Disease / surgery*
Hospitals, University
Infection / epidemiology,  etiology*,  mortality
Liver Transplantation / adverse effects*
Living Donors*
Middle Aged
Postoperative Complications / epidemiology,  etiology*,  mortality,  prevention & control
Preoperative Care
Retrospective Studies
Risk Factors
Sepsis / epidemiology,  etiology,  mortality,  prevention & control
Young Adult
Reg. No./Substance:
0/Amino Acids, Branched-Chain
Comment In:
Nutrition. 2014 Feb;30(2):241-2   [PMID:  24035055 ]

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