Document Detail


Pre-natal amino acid transport inhibition: long term influences on behavior and protein metabolism.
MedLine Citation:
PMID:  3945659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
DBA/2J mice were exposed in utero, between days 15-18 of gestation, to either of two enzyme inhibitors, previously shown to decrease blood-brain, large-neutral amino acid transport in adults: L-methionine-RS-sulfoximine and 2-imidazolidone-4-carboxylic acid. The young mice demonstrated persistently altered motor behavior relative to saline controls when 40-42 days old and evidence of differences in the entry and incorporation of 14C-valine in brain at up to 80 days of age. The findings suggest that interference with blood-brain amino acid transport in utero has long term consequences. This may be related to some human conditions such as maternal phenylketonuria.
Authors:
S Samuels; C T Randt; I Fish; S A Schwartz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  24     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-03-05     Completed Date:  1986-03-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  143-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism*
Animals
Behavior, Animal / drug effects*
Biological Transport / drug effects
Body Weight / drug effects
Brain / drug effects,  metabolism
Feeding Behavior / drug effects
Female
Imidazoles / pharmacology
Imidazolidines*
Methionine Sulfoximine / pharmacology
Mice
Mice, Inbred DBA
Motor Activity / drug effects
Organ Size / drug effects
Pregnancy
Prenatal Exposure Delayed Effects*
Proteins / metabolism*
Valine / metabolism
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Imidazoles; 0/Imidazolidines; 0/Proteins; 1982-67-8/Methionine Sulfoximine; 41371-53-3/2-imidazolidine-4-carboxylic acid; 7004-03-7/Valine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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