Document Detail

Pre-implantation embryonic loss induced by tributyltin chloride in rats.
MedLine Citation:
PMID:  9001586     Owner:  NLM     Status:  MEDLINE    
The effect of tributyltin chloride (TBTCl) administered during early pregnancy on pregnancy maintenance was evaluated in rats. Inseminated females were orally administered TBTCl at a dose of 0, 8.1, 12.2 or 16.3 mg/kg on day 0 through day 7 of pregnancy. Females were sacrificed on day 20 of pregnancy and pregnancy outcome was determined. Pregnancy failure, which was evidenced by absence of implantation sites, was found in 0 of the 10, in 2 of the 11, in 10 of the 14 and in 10 of the 13 females at 0, 8.1, 12.2 and 16.3 mg/kg, respectively. The rate of pregnancy failure was significantly higher in the 12.2 and 16.3 mg/kg groups than that in the control group. In females with successful pregnancy, the numbers of corpora lutea, implantations and post-implantation loss per litter were comparable across all groups. No increase in the incidence of malformed fetuses was found in any TBTCl-treated groups. Thus it appears that TBTCl causes pregnancy failure after administration during very early pregnancy.
A Harazono; M Ema; Y Ogawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology letters     Volume:  89     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-02-12     Completed Date:  1997-02-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  185-90     Citation Subset:  IM    
National Institute of Health Sciences, Osaka Branch, Japan.
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MeSH Terms
Administration, Oral
Body Weight / drug effects
Embryo Loss / chemically induced
Embryonic Development / drug effects*
Fertility / drug effects*
Fetus / drug effects
Rats, Sprague-Dawley
Reproduction / drug effects
Trialkyltin Compounds / administration & dosage,  toxicity*
Reg. No./Substance:
0/Trialkyltin Compounds; 688-73-3/tributyltin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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