Document Detail


Pre-hospital Resuscitation with HBOC-201 and rFVIIa Compared to HBOC-201 Alone in Uncontrolled Hemorrhagic Shock in Swine.
MedLine Citation:
PMID:  21806503     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract In a previous dose escalation study our group found that combining 90μg/kg rFVIIa with HBOC-201 reduced blood loss and improved physiologic parameters compared to HBOC alone. In this follow-up study in a swine liver injury model, we found that while there were no adverse hematology effects and trends observed in the previous study were confirmed, statistical significance could not be reached. Additional pre-clinical studies are indicated to identify optimal components of a multifunctional blood substitute for clinical use in trauma.
Authors:
Ashraful Haque; Françoise Arnaud; Kohsuke Teranishi; Tomoaki Okada; Bobby Kim; Paula F Moon-Massat; Charles Auker; Richard McCarron; Daniel Freilich; Anke H Scultetus
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-2
Journal Detail:
Title:  Artificial cells, blood substitutes, and immobilization biotechnology     Volume:  -     ISSN:  1532-4184     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431307     Medline TA:  Artif Cells Blood Substit Immobil Biotechnol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Naval Medical Research Center, Operational and Undersea Medicine Directorate, NeuroTrauma Department , Silver Spring, MD , USA.
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