Document Detail


Preexisting epithelial diversity in normal human livers: a tissue-tethered cytometric analysis in portal/periportal epithelial cells.
MedLine Citation:
PMID:  23150208     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Novel imaging and computational tools enable increased information extraction from tissue samples and quantify the considerable preexistent hybrid epithelial diversity in normal human liver. This computationally enabled tissue analysis approach offers much broader potential beyond the results presented here.
Authors:
Kumiko Isse; Andrew Lesniak; Kedar Grama; John Maier; Susan Specht; Marcela Castillo-Rama; John Lunz; Badrinath Roysam; George Michalopoulos; Anthony J Demetris
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2013-03-19
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-09     Completed Date:  2013-07-05     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1632-43     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Biliary Tract / cytology,  metabolism
Epithelial Cells / cytology*,  metabolism
Hepatocyte Nuclear Factor 1-beta / metabolism
Hepatocyte Nuclear Factor 4 / metabolism
Hepatocytes / cytology,  metabolism
Humans
Image Cytometry / methods*
Keratin-19 / metabolism
Liver / cytology*,  metabolism
Phenotype*
Grant Support
ID/Acronym/Agency:
N01 AI015416/AI/NIAID NIH HHS; N01-AI-15416/AI/NIAID NIH HHS; P01 AI064343/AI/NIAID NIH HHS; P01-A1-064343//PHS HHS; R01 CA135509/CA/NCI NIH HHS; R01 EB005157/EB/NIBIB NIH HHS; R01-AI-081678/AI/NIAID NIH HHS; R01-EB-005157/EB/NIBIB NIH HHS; T32 AI074490/AI/NIAID NIH HHS; U01-A1-077867//PHS HHS
Chemical
Reg. No./Substance:
0/HNF1B protein, human; 0/HNF4A protein, human; 0/Hepatocyte Nuclear Factor 4; 0/Keratin-19; 138674-15-4/Hepatocyte Nuclear Factor 1-beta
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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