Document Detail


Pre-erythrocytic stages of plasmodia. Role of specific and nonspecific factors.
MedLine Citation:
PMID:  3067797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Protection against pre-erythrocytic stages of malaria is possible as demonstrated by the generation of resistance after immunization with irradiated sporozoites. However, mechanisms involved are more numerous and intricate than previously believed and it progressively appears that the role of the presumed target, the sporozoite, might be negligible compared with that of the hepatic stage. The comparative use of in vivo and in vitro models clearly demonstrates that the intrahepatocytic parasite can be the target of antibodies, cytokines, phagocytic and cytotoxic cells, nonspecific factors--mechanisms in part induced by the previous or subsequent developmental stages.
Authors:
D Mazier; F Miltgen; S Nudelman; A Nussler; L Renia; S Pied; J Goma; M Gentilini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Biology of the cell / under the auspices of the European Cell Biology Organization     Volume:  64     ISSN:  0248-4900     ISO Abbreviation:  Biol. Cell     Publication Date:  1988  
Date Detail:
Created Date:  1989-04-18     Completed Date:  1989-04-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8108529     Medline TA:  Biol Cell     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  165-72     Citation Subset:  IM    
Affiliation:
INSERM U 313, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Host-Parasite Interactions
Plasmodium / physiology*

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