| Pre-emptive analgesic efficacy of tramadol compared with morphine after major abdominal surgery. | |
| | |
MedLine Citation:
|
PMID: 12878619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Studies of pre-emptive analgesia in humans have shown conflicting results. This prospective, randomized, double-blind, controlled study was designed to test the hypothesis that a reduction in postoperative morphine consumption can be achieved by tramadol administered after induction of anaesthesia. METHODS: Ninety patients were allocated randomly to receive i.v. tramadol (1 mg kg(-1)) (Group T), morphine (0.1 mg kg(-1)) (Group M) or saline 2 ml (Group S) after induction of anaesthesia. At peritoneal closure, a standardized (0.1 mg kg(-1)) morphine loading dose was given to all patients for postoperative pain management. Patients were allowed to use a patient-controlled analgesia (PCA) device giving bolus doses of morphine 0.025 mg kg(-1). Discomfort, sedation, pain scores, cumulative morphine consumption, and side-effects were recorded at 1, 2, 6, 12 and 24 h after the start of PCA. RESULTS: There were no significant differences between groups in mean pain, discomfort, and sedation scores at any study period. Cumulative morphine consumption was significantly lower in Group M at 12 and 24 h after starting the PCA than in Group S. In Group T, it was lower only after 24 h (28% less in Group M and 17% less in Group T; P<0.017). There were no significant differences in morphine consumption between Groups T and M. CONCLUSIONS: Tramadol (1 mg kg(-1)), administered after induction of anaesthesia, offered equivalent postoperative pain relief, and similar recovery times and postoperative PCA morphine consumption compared with giving morphine 0.1 mg kg(-1). These results also suggest that presurgical exposure to systemic opioid analgesia may not result in clinically significant benefits . |
| | |
Authors:
|
H Unlugenc; M Ozalevli; Y Gunes; T Guler; G Isik |
Related Documents
:
|
3561529 - The role of descending inhibition in the antinociceptive effects of the pyrazolone deri... 17376409 - Agmatine blocks morphine-evoked hyperthermia in rats. 9732379 - Comparing the subjective, psychomotor and physiological effects of intravenous pentazoc... 1698039 - Depression of ventilatory responses to hypoxia and hypercapnia after pentamorphone. 20142299 - Effects of a rhodiola rosea l. extract on acquisition and expression of morphine tolera... 10771039 - The novel kappa-opioid receptor agonist trk-820 has no affect on the development of ant... 11732529 - Serotonergic receptor antagonists alter responses to general anaesthetics in rats. 7776829 - The endogenous cannabinoid receptor ligand, anandamide, inhibits the motor behavior: ro... 10913229 - Involvement of ltd(4)in allergic pulmonary inflammation in mice: modulation by cyslt(1)... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: British journal of anaesthesia Volume: 91 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 2003 Aug |
Date Detail:
|
Created Date: 2003-07-24 Completed Date: 2003-09-09 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: England |
Other Details:
|
Languages: eng Pagination: 209-13 Citation Subset: IM |
Affiliation:
|
Cukurova University Faculty of Medicine, Department of Anaesthesiology, 01330 Adana, Turkey. unlugenc@cu.edu.tr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abdomen
/
surgery Adult Analgesia, Patient-Controlled Analgesics, Opioid / administration & dosage, therapeutic use* Double-Blind Method Drug Administration Schedule Female Humans Male Middle Aged Morphine / administration & dosage, therapeutic use* Pain Measurement / methods Pain, Postoperative / prevention & control* Prospective Studies Tramadol / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Analgesics, Opioid; 27203-92-5/Tramadol; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of different quantitative sensory testing methods during remifentanil infusion in volunte...
Next Document: Nausea and vomiting after fast-track cardiac anaesthesia.