Document Detail

Pre-emptive analgesic efficacy of tramadol compared with morphine after major abdominal surgery.
MedLine Citation:
PMID:  12878619     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Studies of pre-emptive analgesia in humans have shown conflicting results. This prospective, randomized, double-blind, controlled study was designed to test the hypothesis that a reduction in postoperative morphine consumption can be achieved by tramadol administered after induction of anaesthesia. METHODS: Ninety patients were allocated randomly to receive i.v. tramadol (1 mg kg(-1)) (Group T), morphine (0.1 mg kg(-1)) (Group M) or saline 2 ml (Group S) after induction of anaesthesia. At peritoneal closure, a standardized (0.1 mg kg(-1)) morphine loading dose was given to all patients for postoperative pain management. Patients were allowed to use a patient-controlled analgesia (PCA) device giving bolus doses of morphine 0.025 mg kg(-1). Discomfort, sedation, pain scores, cumulative morphine consumption, and side-effects were recorded at 1, 2, 6, 12 and 24 h after the start of PCA. RESULTS: There were no significant differences between groups in mean pain, discomfort, and sedation scores at any study period. Cumulative morphine consumption was significantly lower in Group M at 12 and 24 h after starting the PCA than in Group S. In Group T, it was lower only after 24 h (28% less in Group M and 17% less in Group T; P<0.017). There were no significant differences in morphine consumption between Groups T and M. CONCLUSIONS: Tramadol (1 mg kg(-1)), administered after induction of anaesthesia, offered equivalent postoperative pain relief, and similar recovery times and postoperative PCA morphine consumption compared with giving morphine 0.1 mg kg(-1). These results also suggest that presurgical exposure to systemic opioid analgesia may not result in clinically significant benefits .
H Unlugenc; M Ozalevli; Y Gunes; T Guler; G Isik
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  91     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-24     Completed Date:  2003-09-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  England    
Other Details:
Languages:  eng     Pagination:  209-13     Citation Subset:  IM    
Cukurova University Faculty of Medicine, Department of Anaesthesiology, 01330 Adana, Turkey.
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MeSH Terms
Abdomen / surgery
Analgesia, Patient-Controlled
Analgesics, Opioid / administration & dosage,  therapeutic use*
Double-Blind Method
Drug Administration Schedule
Middle Aged
Morphine / administration & dosage,  therapeutic use*
Pain Measurement / methods
Pain, Postoperative / prevention & control*
Prospective Studies
Tramadol / therapeutic use*
Reg. No./Substance:
0/Analgesics, Opioid; 27203-92-5/Tramadol; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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