Document Detail

Pre-ejection period variations predict the fluid responsiveness of septic ventilated patients.
MedLine Citation:
PMID:  16276164     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: In septic patients with acute circulatory failure, reliable predictors of fluid responsiveness are needed at the bedside. We hypothesized that the respiratory change in pre-ejection period (DeltaPEP) would allow the prediction of changes in cardiac index following volume administration in mechanically ventilated septic patients. DESIGN: Prospective clinical investigation. SETTING: A ten-bed hospital intensive care unit. PATIENTS: Patients admitted after septic shock equipped with an arterial catheter. INTERVENTIONS: Pre-ejection period (PEP)--defined as the time interval between the beginning of the R wave on the electrocardiogram and the upstroke of the radial arterial pressure curve (PEPKT) or the pulse plethysmographic waveforms (PEPPLET)--and cardiac index (transthoracic echocardiography-Doppler) were determined before and after volume infusion of colloid (8 mL x kg). DeltaPEP (%) was defined as the difference between expiratory and inspiratory PEP divided by the mean of expiratory and inspiratory values. Respiratory changes in pulse pressure (DeltaPP) was also measured. MEASUREMENTS AND MAIN RESULTS:: Twenty-two volume challenges were done in 20 deeply sedated patients. DeltaPEPKT, DeltaPEPPLET, and DeltaPP (measured in all patients) before volume expansion were correlated with cardiac index change after fluid challenge (r = .73, r = .67, and r = .70, respectively, p < .0001). Patients with a cardiac index increase induced by volume expansion > or = 15% and <15% were classified as responders and nonresponders, respectively. Receiver operating characteristic curves showed that the threshold DeltaPP value of 17% allowed discrimination between responder/nonresponder patients with a sensitivity of 85% and a specificity of 100%. For both DeltaPEPKT and DeltaPEPPLET, the best threshold value was 4% with a sensitivity-specificity of 92%-89% and 100%-67%, respectively. CONCLUSIONS: The present study found DeltaPEPKT and DeltaPEPPLET to be as accurate as DeltaPP in the prediction of fluid responsiveness in mechanically ventilated septic patients.
Marc Feissel; Julio Badie; Paolo G Merlani; Jean-Pierre Faller; Karim Bendjelid
Related Documents :
8400154 - A model of the factors affecting interstitial volume in oedema. part iii: partial deriv...
21976274 - Validation of the noninvasive assessment of central blood pressure by the sphygmocor an...
17886624 - Brain natriuretic peptide and impedance cardiography to assess volume status in periton...
6519764 - Effect of raised portal venous pressure on blood pressure, urine output and body fluids.
17946674 - Non-restrictive heart rate monitoring using an acceleration sensor.
3215874 - Airway responsiveness to inhaled and intravenous carbachol in sheep: effect of airway m...
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  33     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-08     Completed Date:  2005-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2534-9     Citation Subset:  AIM; IM    
Intensive Care Unit, Centre Hospitalier, Belfort, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cardiac Output*
Fluid Therapy
Intensive Care Units
Middle Aged
Predictive Value of Tests
Prospective Studies
Respiration, Artificial*
Sepsis / mortality,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Intralesional methotrexate for keratoacanthoma of the nose.
Next Document:  Prophylactic fenoldopam for renal protection in sepsis: a randomized, double-blind, placebo-controll...