Document Detail


Pre-eclampsia following chemotherapy for breast cancer during pregnancy: case report and review of the literature.
MedLine Citation:
PMID:  22395860     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: There has been some discussion about the effect of antineoplastic agents on the trophoblast, and whether this is associated with abnormal placental function such as an increased risk of pre-eclampsia/eclampsia. We discuss a possible causal relationship between chemotherapy for breast cancer during pregnancy and the development of pre-eclampsia based on the occurrence of both in a recent pregnancy.
METHODS: We report the case of a 34-year-old gravida 4, para 1 with unilateral ductal invasive breast cancer, treated by surgery and subsequent chemotherapy during pregnancy. At 36 + 2 weeks of gestation a growth restricted male infant (1,680 g, <5th percentile) was born by urgent caesarean section because of acute pre-eclampsia, pathologic CTG and umbilical end-diastolic reverse flow. This case is reported in detail, and literature and databases reviewed.
RESULTS: So far there have been no reports suggesting an increased risk of pre-eclampsia following chemotherapy for breast cancer in pregnancy from the second trimester onwards, and the most probable is an accidental occurrence from pre-eclampsia and chemotherapy.
CONCLUSIONS: Whenever possible, pregnant patients with breast cancer should receive the same treatment as those who are not pregnant. Should chemotherapy for breast cancer be indicated in pregnancy from the second trimester onwards only, contraindications would be other risks for pre-eclampsia and intrauterine growth restriction, such as smoking and gestational diabetes.
Authors:
L Massey Skatulla; S Loibl; B Schauf; T Müller
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2012-03-07
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  286     ISSN:  1432-0711     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-13     Completed Date:  2012-12-07     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  89-92     Citation Subset:  IM    
Affiliation:
Oberärztin Frauenklinik, Klinikum Hanau GmbH, Hanau, Germany. Luzie_Massey-Skatulla@klinikum-hanau.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Antineoplastic Combined Chemotherapy Protocols / adverse effects*,  therapeutic use
Breast Neoplasms / drug therapy*
Carcinoma, Ductal, Breast / drug therapy*
Cesarean Section
Cyclophosphamide / administration & dosage
Female
HELLP Syndrome / chemically induced*
Humans
Infant, Newborn
Male
Pre-Eclampsia / chemically induced*
Pregnancy
Pregnancy Complications, Neoplastic / drug therapy*
Taxoids / administration & dosage
Chemical
Reg. No./Substance:
0/Taxoids; 15H5577CQD/docetaxel; 50-18-0/Cyclophosphamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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