Document Detail

Pre-eclampsia: fitting together the placental, immune and cardiovascular pieces.
MedLine Citation:
PMID:  20593492     Owner:  NLM     Status:  MEDLINE    
The success of pregnancy is a result of countless ongoing interactions between the placenta and the maternal immune and cardiovascular systems. Pre-eclampsia is a serious pregnancy complication that arises from multiple potential aberrations in these systems. The pathophysiology of pre-eclampsia is established in the first trimester of pregnancy, when a range of deficiencies in placentation affect the key process of spiral artery remodelling. As pregnancy progresses to the third trimester, inadequate spiral artery remodelling along with multiple haemodynamic, placental and maternal factors converge to activate the maternal immune and cardiovascular systems, events which may in part result from increased shedding of placental debris. As we understand more about the pathophysiology of pre-eclampsia, it is becoming clear that the development of early- and late-onset pre-eclampsia, as well as intrauterine growth restriction (IUGR), does not necessarily arise from the same underlying pathology.
Joanna L James; Guy S Whitley; Judith E Cartwright
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Journal of pathology     Volume:  221     ISSN:  1096-9896     ISO Abbreviation:  J. Pathol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-07     Completed Date:  2010-08-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  363-78     Citation Subset:  IM    
Division of Basic Medical Sciences, St George's University of London, London, UK.
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MeSH Terms
Fetal Growth Retardation / physiopathology
Placenta / blood supply,  immunology,  physiopathology*
Placentation / physiology
Pre-Eclampsia / etiology,  immunology,  physiopathology*
Trophoblasts / physiology

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