Document Detail


Pre- and early post-partum adiponectin and interleukin-1beta levels in women with and without gestational diabetes.
MedLine Citation:
PMID:  18694861     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate maternal serum adiponectin and Interleukin-1beta (IL-1beta) levels during the pre- and post-partum periods in pregnant women with and without gestational diabetes mellitus (GDM).
DESIGN: Thirty control pregnant Caucasian women without GDM and thirty body mass index (BMI) and age-matched Caucasian women with GDM examined in the outpatient clinic between the 24th and 26th week of their pregnancy and on the 3rd day postpartum underwent anthropometry and had serum blood taken. Both groups, were monitored by a dietitian and had comparable weight gain during pregnancy. Birth weight was also measured.
RESULTS: At the 3rd day postpartum, compared to the 2nd trimester of pregnancy, women with GDM had lower serum adiponectin levels, lower serum IL-1beta levels and lower homeostasis model assessment for insulin resistance (HOMA-IR) values. At the 2nd trimester of pregnancy, women with GDM had lower serum adiponectin levels, higher IL-1beta and higher HOMA-IR values compared to women without GDM. At the 3rd day postpartum, women with GDM had lower serum adiponectin levels, higher IL-1beta and higher HOMA-IR values compared to women without GDM. Second trimester serum adiponectin values of women with GDM correlated negatively with birth weight.
CONCLUSIONS: Gestational diabetes is a state of insulin resistance associated with altered levels of proinflammatory cytokines, increased IL-1beta and decreased adiponectin values. Both of these alterations might be attributed to placental pathology in pregnancies with GDM.
Authors:
Nikolaos Vitoratos; Georgios Valsamakis; George Mastorakos; Anastassios Boutsiadis; Nikolaos Salakos; Evagelia Kouskouni; George Creatsas
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hormones (Athens, Greece)     Volume:  7     ISSN:  1109-3099     ISO Abbreviation:  Hormones (Athens)     Publication Date:    2008 Jul-Sep
Date Detail:
Created Date:  2008-08-12     Completed Date:  2008-09-25     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  101142469     Medline TA:  Hormones (Athens)     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  230-6     Citation Subset:  IM    
Affiliation:
2nd Department of Obstetrics and Gynecology, Aretaieion University Hospital, Athens University Medical School, Athens, Greece. nikolasvitoratos@yahoo.gr
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / blood
Adult
Birth Weight
Case-Control Studies
Diabetes, Gestational / metabolism*,  physiopathology
Female
Humans
Infant, Newborn
Insulin Resistance
Interleukin-1beta / blood*
Postpartum Period
Pregnancy
Pregnancy Trimester, Second
Prospective Studies
Chemical
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin; 0/Interleukin-1beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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