| Pre-disease pregnancy complications and systemic sclerosis: pathogenic or pre-clinical? | |
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MedLine Citation:
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PMID: 22313964 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACT: The fetal microchimerism theory for the pathogenesis of systemic sclerosis (SSc) has compelling biologic support, including the female predominance of the disease, the mean age of onset after childbearing years, similarities between diffuse cutaneous SSc and graft-versus-host disease, as well as the detection of microchimeric cells in peripheral blood and skin of SSc patients. The previous issue of Arthritis Research and Therapy presents findings of a positive association between pregnancy complications and future diagnosis of SSc in parous women. Before interpreting the results of this epidemiologic study as support for fetal microchimerism, however, other theories for the observed associations must be considered. |
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Authors:
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Eliza Chakravarty |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-6 |
Journal Detail:
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Title: Arthritis research & therapy Volume: 14 ISSN: 1478-6362 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101154438 Medline TA: Arthritis Res Ther Country: - |
Other Details:
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Languages: ENG Pagination: 102 Citation Subset: - |
Affiliation:
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Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA. chakravartye@omrf.org. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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