Document Detail

Prediagnostic circulating adipokine concentrations and risk of renal cell carcinoma in male smokers.
MedLine Citation:
PMID:  23042303     Owner:  NLM     Status:  MEDLINE    
Despite a well-established link between obesity and renal cell carcinoma (RCC), the mechanism through which obesity acts to increase cancer risk is unclear. Adiponectin, leptin and resistin are adipocyte-secreted peptide hormones that may influence RCC development through their demonstrated effects on inflammation, insulin resistance and cell growth and proliferation. We conducted a nested case-control study to evaluate whether prediagnostic serum adiponectin, leptin and resistin levels are associated with RCC risk. This case-control study (273 cases and 273 controls) was nested within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort of Finnish male smokers. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated using conditional logistic regression models, with analyte levels modeled continuously and categorically (defined using quartiles among controls). High adiponectin levels were significantly associated with reduced RCC risk (Quartile 4 versus Quartile 1: OR = 0.52, 95% CI = 0.30-0.88; P trend = 0.01). This association remained upon additional adjustment for body mass index at blood collection and exclusion of cases diagnosed within the first 2 years of follow-up. In addition, model adjustment for adiponectin resulted in a substantial attenuation of the association between BMI and RCC (OR per 5 kg/m(2) changed from 1.19 to 1.05). No clear associations with RCC were observed for leptin or resistin. Our results suggest that elevated levels of circulating adiponectin are associated with decreased subsequent risk of RCC. These findings provide the strongest evidence to date, suggesting that the association between obesity and RCC is mediated at least in part through the effects of low adiponectin.
Linda M Liao; Stephanie J Weinstein; Michael Pollak; Zhen Li; Jarmo Virtamo; Demetrius Albanes; Wong-Ho Chow; Mark P Purdue
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2012-10-06
Journal Detail:
Title:  Carcinogenesis     Volume:  34     ISSN:  1460-2180     ISO Abbreviation:  Carcinogenesis     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-03     Completed Date:  2013-02-25     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  England    
Other Details:
Languages:  eng     Pagination:  109-12     Citation Subset:  IM    
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MeSH Terms
Adipokines / blood*
Carcinoma, Renal Cell / blood,  epidemiology*
Case-Control Studies
Kidney Neoplasms / blood,  epidemiology*
Middle Aged
Smoking / blood*
Grant Support
HHSN261201000006C//PHS HHS; N01-CN-45165/CN/NCI NIH HHS; N01-RC-37004/RC/CCR NIH HHS; N01-RC-45035/RC/CCR NIH HHS; ZIA CP010195-06/CP/NCI NIH HHS
Reg. No./Substance:
Comment In:
J Urol. 2013 Sep;190(3):863   [PMID:  23931186 ]

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