Document Detail

Pre-decapitation state of arousal of rats predetermines the effect of des-Tyr1-gamma-endorphin on dopamine release from nucleus accumbens slices in vitro.
MedLine Citation:
PMID:  6717245     Owner:  NLM     Status:  MEDLINE    
The non-opiate beta-endorphin fragment des-Tyr1-gamma-endorphin (DT gamma E) had a decreasing effect on K+-induced release of tritiated dopamine from nucleus accumbens slices in vitro, when tissue was used of rats which prior to decapitation were in a state of low arousal. When nucleus accumbens tissue was used of rats which were mildly stressed by exposure to a novel environment prior to decapitation, this effect was absent, while an enhancing effect of DT gamma E became evident on basal dopamine efflux. This latter effect resembled that of haloperidol, which dose-dependently enhanced basal dopamine efflux in vitro. Exposure of rats to ether vapor shortly before decapitation abolished both these in vitro effects of DT gamma E. The results are interpreted as indicating that the quality of the modulating effects of DT gamma E on dopamine release from dopaminergic neurons projecting to the nucleus accumbens is depending on the state of activity of these neurons, which, in its turn, is a reflection of the state of arousal of the rats.
D H Versteeg; D Van Heuven-Nolsen; D De Wied
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  34     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-06-14     Completed Date:  1984-06-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1549-54     Citation Subset:  IM    
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MeSH Terms
Arousal / physiology*
Behavior, Animal
Dopamine / secretion*
Endorphins / pharmacology*
Haloperidol / pharmacology
Nucleus Accumbens / drug effects,  secretion*
Peptide Fragments / pharmacology*
Potassium / pharmacology
Rats, Inbred Strains
Septal Nuclei / secretion*
Stress, Physiological / metabolism*
Reg. No./Substance:
0/Endorphins; 0/Peptide Fragments; 52-86-8/Haloperidol; 67810-56-4/gamma-endorphin, des-Tyr(1)-; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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