| Pre-clinical diabetic cardiomyopathy: prevalence, screening, and outcome. | |
| | |
MedLine Citation:
|
PMID: 20581103 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: Diabetic cardiomyopathy, characterized by left ventricular (LV) dysfunction and LV hypertrophy independent of myocardial ischaemia and hypertension, could contribute to the increased life-time risk of congestive heart failure seen in patients with diabetes. We assessed prospectively the prevalence, effectiveness of screening methods [brain natriuretic peptide (BNP) and C-reactive protein in combination with clinical parameters], and outcome of pre-clinical diabetic cardiomyopathy. METHODS AND RESULTS: We studied 100 adults (mean age 57.4 +/- 10.2 years, 44% females) with diabetes and no previous evidence of structural heart disease. By echocardiography, diabetic cardiomyopathy was present in 48% of patients. Screening with combinations of clinical parameters (gender, systolic blood pressure, and body mass index), but not BNP, resulted in high negative predictive values for diabetic cardiomyopathy. During a mean follow-up of 48.5 +/- 9.0 months, in the groups with and without diabetic cardiomyopathy, 12.5 vs. 3.9% (P < 0.2) patients died or experienced cardiovascular events and 37.5 vs. 9.6% (P < 0.002) had a deterioration in NYHA functional class. Overall event-free survival was 54 vs. 87% (P = 0.001) in the groups with and without diabetic cardiomyopathy, respectively. Brain natriuretic peptide was an independent predictor of events [odds ratio 3.5 (1.1-10.9), P = 0.02]. CONCLUSION: Pre-clinical diabetic cardiomyopathy is common. Screening with combinations of simple clinical parameters, but not BNP, can be useful to identify those patients needing further evaluation. Patients with pre-clinical diabetic cardiomyopathy are at increased risk for functional deterioration and possibly cardiovascular events during follow-up. Brain natriuretic peptide was shown to be an independent predictor of future events. |
| | |
Authors:
|
Stephanie Kiencke; Rolf Handschin; Ruth von Dahlen; Jürgen Muser; Hans Peter Brunner-Larocca; Jörg Schumann; Barbara Felix; Kaspar Berneis; Peter Rickenbacher |
Related Documents
:
|
2154133 - Na(+)-h+ exchange in cardiac sarcolemmal vesicles isolated from diabetic rats. 3709563 - Mathematical model of the metabolism of 123i-16-iodo-9-hexadecenoic acid in an isolated... 3451413 - Fasting plasma magnesium concentration and its relation to control in diabetic nigerians. |
Publication Detail:
|
Type: Comparative Study; Journal Article Date: 2010-06-25 |
Journal Detail:
|
Title: European journal of heart failure Volume: 12 ISSN: 1879-0844 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-08-23 Completed Date: 2011-01-11 Revised Date: 2011-06-08 |
Medline Journal Info:
|
Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 951-7 Citation Subset: IM |
Affiliation:
|
Cardiology Division, Kantonsspital Bruderholz, CH-4101 Bruderholz, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Diabetic Cardiomyopathies
/
complications,
diagnosis,
epidemiology* Echocardiography, Doppler Electrocardiography Female Follow-Up Studies Humans Hypertrophy, Left Ventricular / complications, diagnosis, epidemiology Immunoassay Male Mass Screening* Middle Aged Natriuretic Peptide, Brain / blood Prevalence Prognosis Prospective Studies Risk Factors Time Factors Ventricular Dysfunction, Left / complications, diagnosis, epidemiology |
| Chemical | |
Reg. No./Substance:
|
114471-18-0/Natriuretic Peptide, Brain |
| Comments/Corrections | |
Comment In:
|
Eur J Heart Fail. 2010 Sep;12(9):898-900
[PMID:
20729373
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Functional consequences of the collagen/elastin switch in vascular remodeling in hyperhomocysteinemi...
Next Document: ABCG5/G8 polymorphisms and markers of cholesterol metabolism: systematic review and meta-analysis.