Document Detail


Pre-clinical Validation of Orthotopically-implanted Pulmonary Tumor by Imaging with 18F-Fluorothymidine-Positron Emission Tomography/Computed Tomography.
MedLine Citation:
PMID:  24222108     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The development of positron-emission tomography (PET) and X-ray computed tomography (CT) imaging has improved the detection of tumor burden and, in turn, pre-clinical drug development and clinical treatment. In pre-clinical drug development, clinically-relevant murine cancer models, such as orthotopic models of lung cancer, have provided an accurate representation of tumor burden in humans. However, evidence demonstrating the capability of imaging-guided evaluation of these clinically-relevant models is limited. Here, we combined (18)F-fluorothymidine (FLT)-PET/CT imaging and a murine model of human non-small cell lung cancer (NSCLC) to improve the accuracy of anticancer drug evaluation in pre-clinical studies. We found that FLT-PET/CT imaging enabled the progression of pulmonary tumors to be longitudinally monitored rather than FDG-PET/CT. Furthermore, in an efficacy study of a standard treatment of docetaxel in a murine lung cancer model, FLT-PET imaging detected the anticancer response earlier than volumetric analysis by CT imaging. We, thus, observed a relationship between the alteration of FLT signals and Ki-67 index in the pulmonary tumor during the period of chemotherapy. These results indicate that the combination of FLT-PET/CT imaging and an orthotopic NSCLC model is an effective strategy for evaluating clinical efficacy and potential of an anticancer agent during pre-clinical development.
Authors:
Hiroshi Fushiki; Sosuke Miyoshi; Akihiro Noda; Yoshihiro Murakami; Hiroshi Sasaki; Makoto Jitsuoka; Keisuke Mitsuoka; Ichiro Matsunari; Shintaro Nishimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  33     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  4741-9     Citation Subset:  IM    
Affiliation:
Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki, 305-8585 Japan. hiroshi.fushiki@astellas.com.
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