Document Detail


Pre- and postnatal health: evidence of increased choline needs.
MedLine Citation:
PMID:  20656095     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Choline, a micronutrient found in food, serves as the starting material for several important metabolites that play key roles in fetal development, particularly the brain. Although human beings' requirement for choline is unknown, an Adequate Intake level of 425 mg/day was established for women with upward adjustments to 450 and 550 mg/day during pregnancy and lactation, respectively. The importance of choline in human development is supported by observations that a human fetus receives a large supply of choline during gestation; pregnancy causes depletion of hepatic choline pools in rats consuming a normal diet; human neonates are born with blood levels that are three times higher than maternal blood concentrations; and large amounts of choline are present in human milk. The development of the central nervous system is particularly sensitive to choline availability with evidence of effects on neural tube closure and cognition. Existing data show that the majority of pregnant (and presumably lactating) women are not achieving the target intake levels and that certain common genetic variants may increase requirements for choline beyond current recommendations. Because choline is not found in most varieties of prenatal vitamins (or regular multivitamins), increased consumption of choline-rich foods may be needed to meet the high pre- and postnatal demands for choline.
Authors:
Marie A Caudill
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Journal of the American Dietetic Association     Volume:  110     ISSN:  1878-3570     ISO Abbreviation:  J Am Diet Assoc     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-08-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503061     Medline TA:  J Am Diet Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1198-206     Citation Subset:  AIM; IM    
Copyright Information:
2010 American Dietetic Association. Published by Elsevier Inc. All rights reserved.
Affiliation:
Cornell University, Division of Nutritional Sciences, 228 Savage Hall, Ithaca, NY, USA. mac379@cornell.edu
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MeSH Terms
Descriptor/Qualifier:
Choline / administration & dosage*,  physiology
Female
Fetal Development / drug effects*,  physiology
Humans
Infant Nutritional Physiological Phenomena / physiology*
Infant, Newborn / blood*,  growth & development
Maternal Nutritional Physiological Phenomena / physiology*
Milk, Human / chemistry
Nutrition Policy
Nutritional Requirements*
Perinatal Care
Pregnancy / blood
Chemical
Reg. No./Substance:
62-49-7/Choline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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