Document Detail

Pre-operative intravenous dexamethasone prevents auditory threshold shift in a Guinea pig model of cochlear implantation.
MedLine Citation:
PMID:  20668374     Owner:  NLM     Status:  In-Data-Review    
Aim: To protect hearing during cochlear implantation with systemic administration of dexamethasone. Methods: Seventeen normal-hearing guinea pigs were randomly allocated to receive an intravenous injection of either normal saline (control), low- (0.2 mg/kg) or high- (2 mg/kg) dose dexamethasone 60 min prior to cochlear implantation. Auditory brainstem response (ABR) threshold shifts (2-32 kHz) were estimated between pre- and 4-week-postoperative levels. Results: ABR threshold shifts (8-32 kHz) observed in control and low-dose steroid groups were significantly reduced in the high-dose steroid group. Conclusions: A single, high-dose injection of intravenous dexamethasone protected hearing during cochlear implantation.
Timothy M Connolly; Hayden Eastwood; Gordana Kel; Halina Lisnichuk; Rachael Richardson; Stephen O'Leary
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Publication Detail:
Type:  Journal Article     Date:  2010-07-29
Journal Detail:
Title:  Audiology & neuro-otology     Volume:  16     ISSN:  1421-9700     ISO Abbreviation:  Audiol. Neurootol.     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606930     Medline TA:  Audiol Neurootol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  137-44     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
Department of Otolaryngology, University of Melbourne, East Melbourne, Vic., Australia.
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