| Pre-B cell acute lymphoblastic leukemia in the newborn. | |
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MedLine Citation:
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PMID: 6593098 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leukemia in the newborn is an infrequent disease that has not been well defined using modern laboratory techniques. We describe two infants, one at birth and one at four weeks, with acute lymphoblastic leukemia. The blasts from each patient were studied in great detail, using a battery of cytochemical and immunologic procedures in addition to ultrastructural studies. Immunologic cell marker studies, not previously reported in congenital leukemia, showed the lymphoblasts from each infant to be of the pre-B cell phenotype. Each infant relapsed, one after a 17-week clinical remission and the other after a 44-week remission. The former has died while the latter is in a second remission. The subtype of pre-B cell acute lymphoblastic leukemia (ALL) which in childhood appears to confer an unfavorable prognosis, may have the same significance in neonatal ALL. |
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Authors:
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C M Spier; C R Kjeldsberg; R O'Brien; J Marty |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Blood Volume: 64 ISSN: 0006-4971 ISO Abbreviation: Blood Publication Date: 1984 Nov |
Date Detail:
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Created Date: 1984-11-30 Completed Date: 1984-11-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1064-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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therapeutic use Female Humans Infant, Newborn Leukemia, Lymphoid* / drug therapy, genetics, immunology Lymphocytes / ultrastructure Male Microscopy, Electron Phenotype Prognosis Receptors, Antigen, B-Cell / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Receptors, Antigen, B-Cell |
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