Document Detail

Pre-B cell acute lymphoblastic leukemia in the newborn.
MedLine Citation:
PMID:  6593098     Owner:  NLM     Status:  MEDLINE    
Leukemia in the newborn is an infrequent disease that has not been well defined using modern laboratory techniques. We describe two infants, one at birth and one at four weeks, with acute lymphoblastic leukemia. The blasts from each patient were studied in great detail, using a battery of cytochemical and immunologic procedures in addition to ultrastructural studies. Immunologic cell marker studies, not previously reported in congenital leukemia, showed the lymphoblasts from each infant to be of the pre-B cell phenotype. Each infant relapsed, one after a 17-week clinical remission and the other after a 44-week remission. The former has died while the latter is in a second remission. The subtype of pre-B cell acute lymphoblastic leukemia (ALL) which in childhood appears to confer an unfavorable prognosis, may have the same significance in neonatal ALL.
C M Spier; C R Kjeldsberg; R O'Brien; J Marty
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood     Volume:  64     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1984-11-30     Completed Date:  1984-11-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1064-6     Citation Subset:  AIM; IM    
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MeSH Terms
Antineoplastic Agents / therapeutic use
Infant, Newborn
Leukemia, Lymphoid* / drug therapy,  genetics,  immunology
Lymphocytes / ultrastructure
Microscopy, Electron
Receptors, Antigen, B-Cell / immunology
Reg. No./Substance:
0/Antineoplastic Agents; 0/Receptors, Antigen, B-Cell

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