Document Detail

Prazosin for vasodilator treatment of acute pulmonary oedema due to scorpion sting.
MedLine Citation:
PMID:  3503648     Owner:  NLM     Status:  MEDLINE    
Prazosin hydrochloride, a post-synaptic alpha receptor blocking agent, was administered to twelve patients with acute pulmonary oedema due to scorpion sting in order to lower their mean blood pressure (diastolic blood pressure plus one-third of pulse pressure) 10 to 20 mmHg. Following an oral dose (0.125 mg in children and 0.5 mg in adults), clinical improvement was seen in the form of disappearance of apical systolic murmur and pulmonary oedema, a reduction in heart rate observed at the end of the first hour, and maximal improvement seen at the end of the third hour. Chest radiographs showed conspicuous clearing of pulmonary oedema. Electrocardiographs (ECG) showed hypoxic injury patterns such as a Q-wave in lead I and AVL with tented T waves in precordial leads, left anterior hemiblock (LAHB) and acute infarction patterns with subsequent T-wave inversion. The severity of clinical signs and ECG changes increased as the time between the sting and attending hospital lengthened.
H S Bawaskar; P H Bawaskar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of tropical medicine and parasitology     Volume:  81     ISSN:  0003-4983     ISO Abbreviation:  Ann Trop Med Parasitol     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-11-23     Completed Date:  1988-11-23     Revised Date:  2009-05-18    
Medline Journal Info:
Nlm Unique ID:  2985178R     Medline TA:  Ann Trop Med Parasitol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  719-23     Citation Subset:  IM    
Rural Hospital, Poladpur, Maharashtra, India.
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MeSH Terms
Acute Disease
Arachnidism / complications*
Child, Preschool
Prazosin / therapeutic use*
Pulmonary Edema / drug therapy*,  etiology
Vasodilator Agents / therapeutic use*
Reg. No./Substance:
0/Vasodilator Agents; 19216-56-9/Prazosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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