| Prazosin treatment of neurological patients with detrusor hyperreflexia and bladder emptying disability. | |
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MedLine Citation:
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PMID: 2678426 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a placebo-controlled clinical trial with cross-over design the effect of alpha-adrenoceptor blockade with prazosin was studied in 18 neurological patients with detrusor hyperreflexia and bladder emptying disability. During active treatment both the distance to maximal urethral closure pressure (MUCP) and MUCP were significantly reduced. In addition, the volume at first bladder contraction was increased. The urodynamic parameters measured during voiding were unaffected. We conclude that prazosin decreases detrusor hyperreflexia but only in rare cases may benefit bladder emptying in these patients. |
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Authors:
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T Petersen; S E Husted; P Sidenius |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of urology and nephrology Volume: 23 ISSN: 0036-5599 ISO Abbreviation: Scand. J. Urol. Nephrol. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-11-17 Completed Date: 1989-11-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0114501 Medline TA: Scand J Urol Nephrol Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 189-94 Citation Subset: IM |
Affiliation:
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Department of Neurology, Arhus Kommunehospital, University Hospital of Arhus, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Male Middle Aged Prazosin / therapeutic use* Randomized Controlled Trials as Topic Urinary Bladder, Neurogenic / drug therapy* Urination Disorders / drug therapy* Urodynamics / drug effects |
| Chemical | |
Reg. No./Substance:
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19216-56-9/Prazosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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