Document Detail

Prazosin in the treatment of hypertension.
MedLine Citation:
PMID:  802633     Owner:  NLM     Status:  MEDLINE    
1. Prazosin decreases blood pressure in normotensive, renal hypertensive and spontaneous hypertensive rats. The effect is greatest in the last-named. 2. In spontaneously hypertensive rats the decrease in pressure is associated with a decrease in heart rate. 3. In hypertensive patients prazosin decreases blood pressure by decreasing total peripheral resistance with minor effects on cardiac output. 4. Prazosin is effective in the long-term therapy of hypertensive patients, alone and in combination with a diuretic. The effect on blood pressure is the same in the supine and standing position.
M Fernandes; I S Smith; A Weder; K E Kim; A B Gould; P Busby; C Swartz; G Onesti
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical science and molecular medicine. Supplement     Volume:  2     ISSN:  0144-4107     ISO Abbreviation:  Clin Sci Mol Med Suppl     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1978-12-02     Completed Date:  1978-12-02     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  7907311     Medline TA:  Clin Sci Mol Med Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  181s-184s     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Cardiac Output / drug effects
Clinical Trials as Topic
Double-Blind Method
Heart Rate / drug effects
Hypertension / drug therapy*,  genetics
Methyldopa / therapeutic use
Prazosin / therapeutic use*
Quinazolines / therapeutic use*
Vascular Resistance / drug effects
Reg. No./Substance:
0/Quinazolines; 19216-56-9/Prazosin; 555-30-6/Methyldopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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