Document Detail

Prazosin improves atherogenic index and inhibits the deleterious effect of dihydrochlorothiazide in patients with essential hypertension.
MedLine Citation:
PMID:  2455187     Owner:  NLM     Status:  MEDLINE    
Twenty-three patients with essential hypertension were treated consecutively with prazosin or dihydrochlorothiazide or the combination of the two, each treatment period lasting for three months. Blood pressure, heart rate (HR), serum levels of total cholesterol, triglycerides, HDL-c and LDL-c, uric acid, glucose, Na, and K were measured during the baseline and at the end of each treatment period. Both prazosin and dihydrochlorothiazide (THI) decreased blood pressure but the effect of the combination was more pronounced than that of the monotherapies. Prazosin had no effect on the plasma level of total cholesterol, triglycerides, uric acid, Na, K, and glucose but increased HDL-c, decreased LDL-c, and thereby significantly improved (decreased) atherogenic index (total cholesterol/HDL-c). THI increased total cholesterol, triglycerides, LDL + VLDL-c, glucose, and uric acid; decreased HDL-c and K levels; and significantly increased the atherogenic index. Prazosin neutralized the effects of THI on total cholesterol, triglycerides, HDL-c, and on LDL + VLDL-c but not on glucose, uric acid, or K. These results suggest that the effects of THI on plasma lipids may be mediated by alpha 1-adrenoceptor-related mechanisms but the effects on glucose, uric acid, and K, probably may not be mediated by these mechanisms.
C Farsang; M Péter; A Balás-Eltes; J Fehér
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  10 Suppl 12     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1987  
Date Detail:
Created Date:  1988-07-29     Completed Date:  1988-07-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S240-3     Citation Subset:  IM    
2nd Department of Medicine, Semmelweis University Medical School, Budapest, Hungary.
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MeSH Terms
Blood Pressure
Cholesterol / blood
Heart Rate
Hydrochlorothiazide / adverse effects*
Hypertension / drug therapy*,  physiopathology
Lipids / blood*
Middle Aged
Prazosin / therapeutic use*
Triglycerides / blood
Uric Acid / blood
Reg. No./Substance:
0/Lipids; 0/Triglycerides; 19216-56-9/Prazosin; 57-88-5/Cholesterol; 58-93-5/Hydrochlorothiazide; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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