Document Detail


Praziquantel for treatment of schistosomiasis in patients with advanced hepatosplenomegaly.
MedLine Citation:
PMID:  3938936     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated praziquantel for therapy of active Schistosoma mansoni infection in 15 rural Egyptian males with hepatosplenic schistosomiasis. Criteria for inclusion in this study were two pre-treatment S. mansoni egg counts with a mean of greater than 100 eggs g-1 faeces and an enlarged spleen. Fourteen of 15 patients had hepatomegaly, five had ascites, and six had serum albumin below 3 g dl-1. Schistosoma haematobium infection (less than 10 eggs ml-1 urine) was present in three patients. Praziquantel was administered in a single oral dose of 30 mg kg-1 body weight. Eight of the 15 patients (53%) had mild and transient reactions in the form of fever (usually one day), gastrointestinal symptoms, headache and skin rash. Criteria for parasitological cure were the absence of live eggs in two stool samples and a negative rectal snip biopsy three months after therapy. Ten patients ceased to pass live eggs (cure rate 67%). For the five who were still passing live eggs there was a mean egg reduction of 95%. The three patients with S. haematobium demonstrated parasitological cures. We conclude that praziquantel is an effective and well tolerated drug for treatment of S. mansoni infection in patients with advanced hepatosplenic schistosomiasis, and it is the drug of choice for patients with coexisting S. haematobium infection.
Authors:
S Bassily; Z Farid; M Dunn; N A el-Masry; M Stek
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Annals of tropical medicine and parasitology     Volume:  79     ISSN:  0003-4983     ISO Abbreviation:  Ann Trop Med Parasitol     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-06-11     Completed Date:  1986-06-11     Revised Date:  2009-05-18    
Medline Journal Info:
Nlm Unique ID:  2985178R     Medline TA:  Ann Trop Med Parasitol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  629-34     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Feces / parasitology
Hepatitis B Surface Antigens / analysis
Hepatomegaly / complications
Humans
Male
Middle Aged
Parasite Egg Count
Praziquantel / therapeutic use*
Schistosomiasis haematobia / complications
Schistosomiasis mansoni / complications,  drug therapy*,  parasitology
Splenomegaly / complications
Chemical
Reg. No./Substance:
0/Hepatitis B Surface Antigens; 55268-74-1/Praziquantel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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