| Pravastatin in acute ischaemic syndromes: results of a randomised placebo-controlled trial. | |
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MedLine Citation:
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PMID: 11452676 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Therapy with individual 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) has been shown conclusively to diminish coronary event rates and mortality in both primary and secondary prevention. To date, scant attention has been paid to whether initiation of such regimens in the hospital phase of acute coronary syndromes might confer cardioprotective benefits. The purpose of this study was to determine the safety and tolerability of early initiation of statin therapy in patients with acute coronary syndromes. In this randomised, double-blind, three-month, pilot study, 100 patients with acute myocardial infarction or unstable angina and low-density lipoprotein cholesterol > 3.5 mmol/l were randomly assigned to pravastatin 40 mg daily or placebo initiated within 48 hours of hospital admission. Pravastatin proved safe and well tolerated in these patients, who were well matched at baseline. No statistically significant differences in death, MI and drug-related adverse events were observed in the pravastatin group compared with control subjects. This pilot study shows that therapy with pravastatin early after an acute coronary event is safe and well tolerated. Larger, long-term studies are needed to confirm these findings. |
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Authors:
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F R Den Hartog; P M Van Kalmthout; T T Van Loenhout; H J Schaafsma; H Rila; F W Verheugt |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: International journal of clinical practice Volume: 55 ISSN: 1368-5031 ISO Abbreviation: Int. J. Clin. Pract. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-07-16 Completed Date: 2001-08-16 Revised Date: 2007-02-14 |
Medline Journal Info:
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Nlm Unique ID: 9712381 Medline TA: Int J Clin Pract Country: England |
Other Details:
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Languages: eng Pagination: 300-4 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Gelderse Vallei Hospital, Ede, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Angina, Unstable / drug therapy*, prevention & control Anticholesteremic Agents / administration & dosage*, adverse effects Double-Blind Method Female Humans Male Middle Aged Myocardial Infarction / drug therapy*, prevention & control Pilot Projects Pravastatin / administration & dosage*, adverse effects Survival Analysis Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 81093-37-0/Pravastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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