| Prasugrel as an alternative for clopidogrel-associated neutropenia. | |
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MedLine Citation:
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PMID: 21791365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clopidogrel has mostly replaced the use of ticlopidine due to its more favourable hematologic adverse event profile. Prasugrel is the newest thienopyridine approved for use in Canada. This case describes a patient who was diagnosed with an acute coronary syndrome and treated with bare metal stenting of his coronary artery. He was discharged home on clopidogrel therapy. Two weeks later he presented with severe neutropenia. Clopidogrel was discontinued and prasugrel was initiated. Neutrophil count gradually increased and returned to normal. In patients with neutropenia associated with clopidogrel therapy, prasugrel may be considered as an alternative. |
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Authors:
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Sanjiv Khangura; Wendy L Gordon |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2011-07-24 |
Journal Detail:
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Title: The Canadian journal of cardiology Volume: 27 ISSN: 1916-7075 ISO Abbreviation: Can J Cardiol Publication Date: 2011 Nov-Dec |
Date Detail:
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Created Date: 2011-11-28 Completed Date: 2012-01-19 Revised Date: 2012-02-28 |
Medline Journal Info:
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Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: England |
Other Details:
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Languages: eng Pagination: 869.e9-11 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pharmacy, Royal Columbian Hospital, Fraser Health, New Westminster, British Columbia, Canada. sanjiv.khangura@fraserhealth.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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diagnosis,
surgery* Aged, 80 and over Coronary Artery Bypass / methods* Coronary Restenosis / prevention & control* Follow-Up Studies Humans Male Neutropenia / blood, chemically induced*, prevention & control Piperazines / administration & dosage* Platelet Aggregation Inhibitors / adverse effects Purinergic P2Y Receptor Antagonists / administration & dosage* Stents Thiophenes / administration & dosage* Ticlopidine / adverse effects, analogs & derivatives*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Piperazines; 0/Platelet Aggregation Inhibitors; 0/Purinergic P2Y Receptor Antagonists; 0/Thiophenes; 0/prasugrel; 55142-85-3/Ticlopidine; 90055-48-4/clopidogrel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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