Document Detail

Prasugrel as an alternative for clopidogrel-associated neutropenia.
MedLine Citation:
PMID:  21791365     Owner:  NLM     Status:  MEDLINE    
Clopidogrel has mostly replaced the use of ticlopidine due to its more favourable hematologic adverse event profile. Prasugrel is the newest thienopyridine approved for use in Canada. This case describes a patient who was diagnosed with an acute coronary syndrome and treated with bare metal stenting of his coronary artery. He was discharged home on clopidogrel therapy. Two weeks later he presented with severe neutropenia. Clopidogrel was discontinued and prasugrel was initiated. Neutrophil count gradually increased and returned to normal. In patients with neutropenia associated with clopidogrel therapy, prasugrel may be considered as an alternative.
Sanjiv Khangura; Wendy L Gordon
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-07-24
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  27     ISSN:  1916-7075     ISO Abbreviation:  Can J Cardiol     Publication Date:    2011 Nov-Dec
Date Detail:
Created Date:  2011-11-28     Completed Date:  2012-01-19     Revised Date:  2012-02-28    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  869.e9-11     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
Department of Pharmacy, Royal Columbian Hospital, Fraser Health, New Westminster, British Columbia, Canada.
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MeSH Terms
Acute Coronary Syndrome / diagnosis,  surgery*
Aged, 80 and over
Coronary Artery Bypass / methods*
Coronary Restenosis / prevention & control*
Follow-Up Studies
Neutropenia / blood,  chemically induced*,  prevention & control
Piperazines / administration & dosage*
Platelet Aggregation Inhibitors / adverse effects
Purinergic P2Y Receptor Antagonists / administration & dosage*
Thiophenes / administration & dosage*
Ticlopidine / adverse effects,  analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/Piperazines; 0/Platelet Aggregation Inhibitors; 0/Purinergic P2Y Receptor Antagonists; 0/Thiophenes; 0/prasugrel; 55142-85-3/Ticlopidine; 90055-48-4/clopidogrel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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