| Pramipexole versus ropinirole: Polysomnographic acute effects in restless legs syndrome. | |
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MedLine Citation:
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PMID: 21370262 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Pramipexole and ropinirole have become the first-line treatment for restless legs syndrome. The aim of this study was to perform the first direct comparison between these two molecules in restless legs syndrome. Methods: A double-blind, placebo-controlled, double-night and prospective investigation was carried out in 45 consecutive naïve patients with idiopathic restless legs syndrome. Each patient underwent two consecutive full-night polysomnographies: the first baseline recording was performed without premedication and, before the second recording, first group received a single oral dose of 0.25 mg pramipexole, second group a single oral dose of 0.5 mg ropinirole, and the remaining patients received placebo. Results and Discussion: Both dopamine agonists improved restless legs syndrome symptoms and markedly suppressed periodic leg movements during sleep compared to placebo, without significant differences between pramipexole and ropinirole. No significant side effects, except for mild morning nausea (2 patients treated with ropinirole, 3 with pramipexole, and 1 with placebo), were reported. © 2010 Movement Disorder Society. |
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Authors:
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Mauro Manconi; Raffaele Ferri; Marco Zucconi; Alessandro Oldani; Laura Giarolli; Valentina Bottasini; Luigi Ferini-Strambi |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-2 |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: - ISSN: 1531-8257 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Movement Disorder Society. |
Affiliation:
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Department of Neurology, Sleep Disorders Center, Scientific Institute and University Ospedale San Raffaele, Vita-Salute University, Milan, Italy; Neurocenter (EOC) of Southern Switzerland, Ospedale Civico, Lugano, Switzerland. manconi.mauro@hsr.it. |
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