Document Detail

Pramipexole reduces the prevalence of fatigue in patients with Parkinson's disease.
MedLine Citation:
PMID:  21963735     Owner:  NLM     Status:  In-Data-Review    
Objective The aim of this multicenter cross-sectional study was to assess the relation between fatigue in a large number of Japanese patients with Parkinson's disease (PD) and drugs taken to treat PD. Method We used the 16-item Parkinson Fatigue Scale (PFS-16), which was designed to assess fatigue exclusively associated with PD. Multiple logistic regression analyses were used to assess the relation between antiparkinson drugs and fatigue in PD. Results A total of 350 non-demented PD patients were enrolled. Fatigue (PFS score of ≥4) was revealed in 319 patients (91%). Pramipexole was administered to 24% of PD patients. Multiple logistic regression analysis revealed that the administration of Pramipexole was significantly related to low rates of fatigue in PD patients with Hoehn and Yahr stage <3 (p=0.011, odds ratio=5.23, 95% confidence interval; 1.47-18.63). Conclusion The reduced fatigue in PD patients was observed in taking Pramipexole.
Akihiko Morita; Yasuyuki Okuma; Satoshi Kamei; Fumihito Yoshii; Toshimasa Yamamoto; Shiori Hashimoto; Hiroya Utsumi; Taku Hatano; Nobutaka Hattori; Miyuki Matsumura; Kazushi Takahashi; Shigeru Nogawa; Yuka Watanabe; Tomoyuki Miyamoto; Masayuki Miyamoto; Koichi Hirata
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Publication Detail:
Type:  Journal Article     Date:  2011-10-01
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  50     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2163-8     Citation Subset:  IM    
Division of Neurology, Department of Medicine, Nihon University School of Medicine, Japan.
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