Document Detail

Pralidoxime in the treatment of carbamate intoxication.
MedLine Citation:
PMID:  2403479     Owner:  NLM     Status:  MEDLINE    
The use of oxime reactivators of inhibited cholinesterase enzymes in poisoning by carbamate compounds has received mixed reviews in the medical literature. Data are limited and inconsistent on the possible role oxime reactivators might have in carbamate intoxication. Based on existing experience, atropine remains the treatment of choice and pralidoxime (2-PAM) is not recommended except in cases where atropine has first been proven inadequate, in serious mixed poisonings with both carbamate and organophosphorus compounds, or in serious poisonings by unidentified cholinesterase inhibitors.
P H Kurtz
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of emergency medicine     Volume:  8     ISSN:  0735-6757     ISO Abbreviation:  Am J Emerg Med     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-07     Completed Date:  1990-02-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8309942     Medline TA:  Am J Emerg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  68-70     Citation Subset:  IM    
California Department of Food and Agriculture, Worker Health and Safety Branch, Sacramento 94271-0001.
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MeSH Terms
Atropine / therapeutic use
Carbamates / poisoning*
Cholinesterase Inhibitors / poisoning
Drug Interactions
Insecticides / poisoning
Pralidoxime Compounds / therapeutic use*
Reg. No./Substance:
0/Carbamates; 0/Cholinesterase Inhibitors; 0/Insecticides; 0/Pralidoxime Compounds; 51-55-8/Atropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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