Document Detail

Pragmatic vs. explanatory: an adaptation of the PRECIS tool helps to judge the applicability of systematic reviews for daily practice.
MedLine Citation:
PMID:  21474282     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The Pragmatic-Explanatory Continuum Indicator Summary (PRECIS) tool was designed to classify randomized clinical trials (RCT) as being more pragmatic or explanatory. We modified the PRECIS tool (called PRECIS-Review tool [PR-tool]) to grade individual trials and systematic reviews of trials. This should help policy makers, clinicians, researchers, and guideline developers to judge the applicability of individual trials and systematic reviews.
STUDY DESIGN AND SETTING: To illustrate the usefulness and applicability of the PR-tool, we applied it to two systematic reviews. Each included RCT was scored on the 10 PRECIS domains on a scale of 1-5. After this scoring, a 10-domain average for each individual trial and for the systematic review a single domain average and an overall average was calculated.
RESULTS: One review was more pragmatic with an average score of 3.7 (range, 2.9-4.6) on our PR-tool, whereas the other review was more explanatory with an average score of 1.9 (range, 1.1-3.3). The results also suggest that the included studies within each systematic review were rather uniform in their approach, although some domains seemed more prone to heterogeneity.
CONCLUSION: The PR-tool provides a useful estimate that gives insight by estimating quantitatively how pragmatic each RCT in the review is, which methodological domains are pragmatic or explanatory, and how pragmatic the review is.
Tjarco Koppenaal; Joris Linmans; J André Knottnerus; Mark Spigt
Publication Detail:
Type:  Journal Article     Date:  2011-04-06
Journal Detail:
Title:  Journal of clinical epidemiology     Volume:  64     ISSN:  1878-5921     ISO Abbreviation:  J Clin Epidemiol     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-08-22     Completed Date:  2011-10-14     Revised Date:  2012-02-27    
Medline Journal Info:
Nlm Unique ID:  8801383     Medline TA:  J Clin Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1095-101     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of General Practice, CAPHRI, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.
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MeSH Terms
Clinical Trials as Topic*
Decision Support Techniques
Research Design / standards
Review Literature as Topic*
Comment In:
J Clin Epidemiol. 2012 Mar;65(3):234-5   [PMID:  22169082 ]

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