| Praeruptorin a inhibits lipopolysaccharide-induced inflammatory response in murine macrophages through inhibition of NF-κB pathway activation. | |
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MedLine Citation:
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PMID: 20842678 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Praeruptorin A (PA) is a pyranocoumarin compound isolated from the dried root of Peucedanum praeruptorum Dunn (Umbelliferae). However, the antiinflammatory effect of PA has not been reported. The present study investigated the antiinflammatory effect of PA in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. PA significantly inhibited the LPS-induced production of nitric oxide (NO), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α). The mRNA and protein expressions of inducible nitric oxide synthase (iNOS), IL-1β and TNF-α were also suppressed by this compound. Further study showed that PA decreased the cytoplasmic loss of inhibitor κB-α (IκB-α) protein and inhibited the translocation of NF-κB from cytoplasm to nucleus. Taken together, the results suggest that PA may exert antiinflammatory effects in vitro in LPS-stimulated RAW 264.7 macrophages through inhibition of NF-κB signal pathway activation. Copyright © 2010 John Wiley & Sons, Ltd. |
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Authors:
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Peng-Jiu Yu; Wei Ci; Guang-Fa Wang; Jun-Yan Zhang; Shao-Yu Wu; Wei Xu; Hong Jin; Zheng-Guang Zhu; Jia-Jie Zhang; Jian-Xin Pang; Shu-Guang Wu |
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Publication Detail:
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Type: Journal Article Date: 2010-09-14 |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 25 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 550-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
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School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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