| Practical tip: Precooling topical calcineurin inhibitors tube; reduces burning sensation. | |
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MedLine Citation:
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PMID: 20409423 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Burning sensation at the site of application is the most common side effect of topical calcineurin inhibitors and is considered the most common reasons for premature discontinuation. Here, we analyze the possible mechanism(s) and offer a simple practical tip to mitigate this adverse effect. Simple cooling of the tube, immediately before use, does reduce the burning sensation and enable most intolerant patients to use the medication comfortably. We also discuss the possible explanation(s) for the success of this maneuver. |
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Authors:
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Sultan Al-Khenaizan |
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Publication Detail:
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Type: Journal Article Date: 2010-04-15 |
Journal Detail:
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Title: Dermatology online journal Volume: 16 ISSN: 1087-2108 ISO Abbreviation: Dermatol. Online J. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-04-22 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610776 Medline TA: Dermatol Online J Country: United States |
Other Details:
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Languages: eng Pagination: 16 Citation Subset: IM |
Affiliation:
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College of Medicine, Division of Dermatology, Department of Medicine, King Abdulaziz Medical City, Riyadh, King Saud Bin Abdulaziz University for Health Sciences. salkhenaizan@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Calcineurin / antagonists & inhibitors* Cold Temperature Dermatitis, Atopic / drug therapy Dermatologic Agents / administration & dosage, adverse effects* Humans Pain / chemically induced, prevention & control* Tacrolimus / administration & dosage, adverse effects*, analogs & derivatives* |
| Chemical | |
Reg. No./Substance:
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0/Dermatologic Agents; 0/pimecrolimus; 109581-93-3/Tacrolimus; EC 3.1.3.16/Calcineurin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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