Document Detail


Practical syntheses of pyridinolines, important amino acidic biomarkers of collagen health.
MedLine Citation:
PMID:  17397226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The paper reports some successful results on the first fully stereoselective total synthesis of the collagen cross-link pyridinolines. All stereogenic centers are stereoselectively introduced using Williams glycine template methodology, and oxazinones are used as a source of chirality and as easily removable protecting groups of the amino acidic functionalities during the assembly of the pyridinoline nucleus.
Authors:
Pietro Allevi; Riccardo Cribiù; Elios Giannini; Mario Anastasia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-31
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  72     ISSN:  0022-3263     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-20     Completed Date:  2007-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3478-83     Citation Subset:  IM    
Affiliation:
Dipartimento di Chimica, Biochimica e Biotecnologie per la Medicina, Università di Milano, via Saldini 50, I-20133 Milano, Italy.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemical synthesis*,  metabolism
Biological Markers / chemistry*,  metabolism
Chemistry, Organic / methods*
Collagen / metabolism*
Humans
Hydroxylysine / chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Biological Markers; 28902-93-4/Hydroxylysine; 63800-01-1/pyridinoline; 90032-33-0/deoxypyridinoline; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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