| Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics. | |
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MedLine Citation:
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PMID: 21174626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present article summarizes the discussions of the 3rd European Science Foundation-University of Barcelona (ESF-UB) Conference in Biomedicine on Pharmacogenetics and Pharmacogenomics, which was held in June 2010 in Spain. It was focused on practical applications in routine medical practice. We provide practical recommendations for ten different clinical situations, that have either been approved or not approved by regulatory agencies. We propose some comments that might accompany the results of these tests, indicating the best drug and doses to be prescribed. The discussed examples include KRAS, cetuximab, panitumumab, EGFR-gefitinib, CYP2D6-tamoxifen, TPMT-azathioprine-6-mercaptopurine, VKORC1/CYP2C9-warfarin, CYP2C19-clopidogrel, HLA-B*5701-abacavir, HLA-B*5701-flucloxacillin, SLCO1B1-statins and CYP3A5-tacrolimus. We hope that these practical recommendations will help physicians, biologists, scientists and other healthcare professionals to prescribe, perform and interpret these genetic tests. |
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Authors:
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Laurent Becquemont; Ana Alfirevic; Ursula Amstutz; Hiltrud Brauch; Evelyne Jacqz-Aigrain; Pierre Laurent-Puig; Miguel A Molina; Mikko Niemi; Matthias Schwab; Andrew A Somogyi; Eric Thervet; Anke-Hilse Maitland-van der Zee; André Bp van Kuilenburg; Ron Hn van Schaik; Céline Verstuyft; Mia Wadelius; Ann K Daly |
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Publication Detail:
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Type: Congresses |
Journal Detail:
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Title: Pharmacogenomics Volume: 12 ISSN: 1744-8042 ISO Abbreviation: Pharmacogenomics Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-22 Completed Date: 2011-04-04 Revised Date: 2011-04-14 |
Medline Journal Info:
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Nlm Unique ID: 100897350 Medline TA: Pharmacogenomics Country: England |
Other Details:
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Languages: eng Pagination: 113-24 Citation Subset: IM |
Affiliation:
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Univ Paris-Sud, Faculty of Medicine Paris-Sud, Pharmacology Department, Assistance Publique Hôpitaux de Paris, Hôpital Bicêtre, Le Kremlin Bicêtre, France. laurent.becquemont@bct.aphp.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Humans Individualized Medicine / methods* Pharmacogenetics / methods* Practice Guidelines as Topic Prescription Drugs* / administration & dosage, adverse effects, pharmacokinetics, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Prescription Drugs |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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