| Practical management of osteoarthritis. Integration of pharmacologic and nonpharmacologic measures. | |
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MedLine Citation:
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PMID: 7496554 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pharmacotherapy should play an adjunctive role to nonpharmacologic measures in the overall management of patients with symptoms due to osteoarthritis. Patients should be instructed in how to rest or unload involved joints; protect them through appropriate manipulation of their environment and appropriate methods of lifting and bending; and maintain and improve muscle strength and flexibility to ensure joint stability and prevent contractures. In most patients, acetaminophen in doses of up to 4 g/d is preferable to nonsteroidal anti-inflammatory drugs (NSAIDs) as a first-choice agent because of its lower toxicity. If NSAIDs are used, they should be prescribed initially in lower (analgesic) doses. Ibuprofen may be the preferred initial NSAID because it can be given in low doses for short durations, has been associated with lower rates of gastrointestinal tract side effects, and is inexpensive. |
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Authors:
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M R Griffin; K D Brandt; M H Liang; T Pincus; W A Ray |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Archives of family medicine Volume: 4 ISSN: 1063-3987 ISO Abbreviation: Arch Fam Med Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1996-01-16 Completed Date: 1996-01-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9300357 Medline TA: Arch Fam Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1049-55 Citation Subset: IM |
Affiliation:
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Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tenn., USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetaminophen
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therapeutic use Analgesics, Opioid / therapeutic use Anti-Inflammatory Agents, Non-Steroidal / therapeutic use* Capsaicin / therapeutic use Codeine / therapeutic use Dextropropoxyphene / therapeutic use Humans Osteoarthritis / drug therapy* Randomized Controlled Trials as Topic |
| Grant Support | |
ID/Acronym/Agency:
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FD-U-000073/FD/FDA HHS; SR01 HS07768-02/HS/AHRQ HHS |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Anti-Inflammatory Agents, Non-Steroidal; 103-90-2/Acetaminophen; 404-86-4/Capsaicin; 469-62-5/Dextropropoxyphene; 76-57-3/Codeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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